Toronto Rehabilitation Institute

Smoothing out the edges: continuous-time estimation with Gaussian process motion priors on factor graphs

Continuous-time state estimation is gaining in popularity due to its abilities to provide smooth solutions, handle asynchronous sensors and interpolate between data points. While there are two main paradigms, parametric (e.g., temporal basis functions, splines) and nonparametric...

Data-driven stochastic reduced-order modelling of parametrized dynamical systems

Abstract Modelling complex dynamical systems under varying conditions is computationally intensive, often rendering high-fidelity simulations intractable. Although reduced-order models (ROMs) offer a promising solution, current methods often struggle with stochastic dynamics and...

Maternal and Fetal Outcomes in Mice Following Exposure to Dolutegravir Alone or in Combination with Lamivudine or Tenofovir Disoproxil Fumarate/Emtricitabine

Abstract Background and Aims Dolutegravir (DTG)-based regimens are widely used in HIV treatment, including during pregnancy, but the contribution of the nucleoside reverse transcriptase inhibitor (NRTI) backbone on maternal and foetal outcomes remains unclear. We examined this in...

Characteristics of individuals with moderate-to-severe traumatic brain injury and predictors of interhospital transfer and specialized rehabilitation: a retrospective cohort study

Abstract Purpose Traumatic brain injury (TBI) is a disabling neurological condition that can cause substantial cognitive, behavioural, and physical health problems for the individual. Currently, it is a leading cause of death for Canadians. Rehabilitation (particularly specialize...

Blood proteomics of menopause map to brain aging and dementia risk

Abstract Menopause is a hallmark process in biological aging that has been implicated in later neurodegenerative risk, but the pathways underlying this connection remain unclear. Here we used blood proteomics data from several cohorts to identify biological changes associated wit...

Conceptualizations of compassion in the context of dementia caregiving: A scoping review protocol

Background Compassion is widely recognized as a vital component of dementia caregiving, yet its conceptualization, definition, and operationalization remain inconsistent across contexts. In dementia caregiving, compassion is often conflated with empathy, emotional labor, and rela...

Augmented reality for hand function rehabilitation: assessing perceptions of feasibility and meaningfulness among individuals with cervical spinal cord injury

Abstract Background: Creating high-quality, home-based rehabilitation tools is integral for hand function recovery among individuals living with cervical spinal cord injury (cSCI). Specifically, the effectiveness of home-based exercises is limited by compliance issues and a lack...

Prevalence and Risk of Heart Failure Among Older Adults Experiencing Homelessness: A Systematic Review and Meta-Analysis

Background Understanding the prevalence and risk of heart failure (HF) among older adults is crucial for informing the design and implementation of interventions and guiding equitable healthcare delivery. Methods A systematic search was conducted in MEDLINE, Embase, Cochrane Data...

Barriers and Facilitators in Using Personal Hearing Amplifiers from the Perspective of Healthcare Providers

Background: Hearing loss is experienced by two-thirds of hospitalized older adults and is associated with poor access to healthcare and negative health outcomes. Personal hearing amplifiers (PHAs) are evidence-based assistive devices provided in many hospitals to improve accessib...

An Environmental Scan of Alternate Level of Care (ALC) Policies in Ontario, Canada

Background: Alternate level of care (ALC) patients occupy hospital beds despite no longer requiring acute services, impacting patient flow and contributing to overcrowding. Ontario hospitals have updated legislation and policies to address this issue, yet protocols vary across ce...

Central Sleep Apnea: Pathophysiology, Diagnosis and Classification.

Central sleep apnea (CSA) is a heterogeneous and relatively rare sleep breathing disorder characterized by recurrent reductions in respiratory drive and airflow during sleep. Its complex and not fully understood pathophysiology reflects challenges in respiratory control mechanism...

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

Lupus Double-Negative B Cells Harbor Expanded Somatic Mutations in Lymphoma-Relevant Pathways

Objectives Systemic lupus erythematosus (SLE) patients have a 2–7-fold increased risk of hematologic malignancies, particularly B-cell non-Hodgkin lymphoma (B-NHL).[1] Although germline susceptibility shared between SLE and B-NHL is minimal,[2] somatic evolution of autoreactive B...