Toranomon Hospital

Healthcare burden and clinical spectrum of symptomatic polycystic liver disease in Japan: a nationwide epidemiological survey

Abstract Background Polycystic liver disease (PLD) is often asymptomatic, but some patients develop symptoms or complications requiring care or intervention. The nationwide burden of symptomatic PLD remains poorly defined. We conducted a nationwide survey to estimate the number a...

Multifocal cutaneous Mycobacterium chelonae infection in a patient with lung cancer and skin lesions mimicking metastasis: a diagnostic and therapeutic challenge and case report

Mycobacterium chelonae is a rapidly growing nontuberculous mycobacterium that can cause severe infection in immunocompromised hosts. Cutaneous involvement may closely resemble metastatic disease, creating substantial diagnostic uncertainty, particularly in patients with advanced...

Sleep-stage dynamics predict current sleep-disordered breathing and future cardiovascular risk

ABSTRACT Sleep-disordered breathing (SDB) is a major contributor to cardiovascular morbidity and disrupts both the macrostructure and dynamics of sleep stages (W, N1, N2, N3, REM). While specific alterations in sleep macrostructure, such as reduced durations of N3 and REM, have b...

Mandibular cortical morphology on dental panoramic radiographs as a potential radiographic marker of frailty in community-dwelling older adults: a retrospective cross-sectional study

Frailty is a multifactorial geriatric syndrome associated with functional decline and adverse health outcomes in older adults. Panoramic radiography is routinely performed in dental practice and enables incidental evaluation of mandibular cortical morphology without additional im...

Angioarchitectural characterization of transdural supply in brain arteriovenous malformations: a multicenter retrospective study

Transdural supply (TDS) is a recognized angioarchitectural feature of brain arteriovenous malformations (bAVMs). We aimed to systematically characterize the angioarchitecture of TDS in bAVMs, focusing on whether transdural feeders terminated within the nidus or connected directly...

Prognostic Impact of Circumferential Resection Margin in Minimally Invasive Surgery for Locally Advanced Rectal Cancer: A Multicenter Prospective Study

ABSTRACT Aim Circumferential resection margin (CRM) status is a well‐established prognostic factor in rectal cancer surgery; however, its long‐term oncological relevance has not been prospectively validated in Japan, where upfront surgery has long been widely used. This study ass...

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surger...

P1.103. Evaluation of the Efficacy of Local Therapy for Postoperative Oligo-Recurrence in Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Management of Metastatic Cancer Background Postoperative recurrence of esophageal squamous cell carcinoma (ESCC) is associated with poor prognosis. Among recurrent patterns, oligo-recurrence (OR) has attracted attention because long-term survival...

Disproportionate expansion of radical prostatectomy among older men in Japan in the robotic surgery era: a nationwide descriptive time series analysis

Abstract Robot-assisted radical prostatectomy (RARP) has rapidly expanded and become the leading surgical approach for prostate cancer in Japan. However, it remains unclear whether the concurrent increase in radical prostatectomy reflects population aging, increased diagnostic ac...

Serum‐derived microribonucleic acids as potential novel biomarkers for slowly progressive type 1 diabetes mellitus

OBJECTIVES: We aimed to identify microribonucleic acids (miRNAs) that could serve as biomarkers for slowly progressive type 1 diabetes mellitus (SPIDDM). MATERIALS AND METHODS: We conducted a retrospective study of adult patients with SPIDDM who fulfilled the criteria for SPIDDM...