Tongren Hospital

Uncovering the microbiota-metabolite axis across levels of metabolic complication burden in Chinese adolescents with obesity

Pediatric obesity presents with diverse metabolic phenotypes, yet the gut microbiota and metabolite signatures associated with obesity-related metabolic complications remain poorly defined. Here, we applied 16S rRNA gene sequencing and untargeted fecal metabolomics to investigate...

METTL3-mediated m6A modification of TP73-AS1 enhances HCC progression by activating Wnt/β-catenin signaling

Long noncoding RNAs (lncRNAs) play key roles in the onset and progression of hepatocellular carcinoma (HCC). Tumor protein 73 antisense RNA 1 (TP73-AS1), a recently identified lncRNA, has been implicated in cancer occurrence, drug resistance, and prognosis; however, its function...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

C-reactive protein–triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with H-type hypertension

Abstract Background The C-reactive protein–triglyceride glucose index (CTI) is a novel composite biomarker that integrates inflammation and insulin resistance. However, its association with the severity of coronary artery disease (CAD) in patients with H-type hypertension under d...

The association between sedentary behavior and eye diseases: a prospective study from the UK Biobank

Abstract Background Sedentary behavior (SB) is a well-established risk factor for multiple chronic diseases. However, evidence regarding its association with common ocular disorders remains limited and inconsistent. This study investigated the prospective associations between SB...