Tongren Hospital

Copper-based targeted nanozyme platform with sequential phototherapy-enzymatic therapy for orchestrating macrophage homeostasis in rheumatoid arthritis

Rheumatoid arthritis (RA) remains a formidable clinical challenge due to the vicious cycle of hyperactivated M1 macrophages, excessive reactive oxygen species (ROS), and sustained pro-inflammatory cytokine storm. Herein, we rationally engineered a targeted copper-based nanozyme p...

A hybrid framework combining enhanced fields and consistent spatial features for stroke lesion segmentation in MR images

Stroke lesion segmentation plays a critical role in clinical diagnosis, prognosis and rehabilitation treatment. However, this task remains highly challenging due to inter-subject differences, shape variations, noise and artifacts in MR images, which hinder the accurate extraction...

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

Evaluation of contrast-enhanced ultrasound-guided fine needle aspiration biopsy in thyroid nodule diagnosis: a study from two tertiary referral centers

PURPOSE: This study aimed to compare the final definitive diagnosis (FDD) rate and accuracy of contrast-enhanced ultrasound (CEUS)-guided fine-needle aspiration biopsy (FNAB) with conventional US-guided FNAB. METHODS: A two-center study was conducted to compare the diagnostic per...

Combined effect of heart disease and high CRP levels on new-onset stroke in middle-aged and older Chinese adults: a prospective cohort study from CHARLS

Abstract Background This study aimed to investigate whether the coexistence of heart disease and high C-reactive protein (CRP) levels increases the risk of new-onset stroke among middle-aged and elderly Chinese individuals. Methods The analysis incluCombined Effect of Heart Disea...

Cu-deficient Cu–Fe Prussian blue analogues enable phosphate/GSH-coupled redox remodeling for catalytic/sonodynamic cancer therapy

Cu–Fe Prussian blue analogues (PBAs) are promising platforms for nanocatalytic medicine owing to their redox-active Cu/Fe centers and open metal–cyano coordination frameworks. Nevertheless, the influence of Cu deficiency on their enzyme-mimetic catalytic behavior in tumor-relevan...

Crystalline topographical construction: endogenous grooves as physical cues for stem cell regulation in bone regeneration

Micro/nano-topographical cues are potent regulators of cellular behavior and function. However, conventional fabrication techniques (e.g., photolithography, nanoimprinting) rely on complex exogenous processing that often induces surface energy loss and impairs biological signal t...

Label-free ovarian cancer histopathological diagnosis using two-photon autofluorescence microscopy with a joint denoising and segmentation framework

Two-photon autofluorescence (TPAF) microscopy is a promising modality for rapid, label-free assessment of unstained tissue, but is fundamentally limited by the poor visibility of nuclei, which are one of the gold-standard cancer biomarkers, due to their negative contrast nature....

Metabolomics analysis of placenta associated with preterm birth and the function of candidate metabolites on decidual senescence

Preterm birth (PTB) is one of the most common adverse pregnancy outcomes, increasing the risk of both short- and long-term complications in infants. While the exact mechanisms of PTB has not been determined, infection and/or inflammatory responses are closely connected with it. L...

Mapping the senescent stromal landscape and altered the immune microenvironment in PCOS endometrium

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder affecting approximately 10% of reproductive-aged women and is a major cause of infertility. Inadequate endometrial receptivity is a pivotal contributor to this infertility, but its underlying cellular mechanisms r...

Uncovering the microbiota-metabolite axis across levels of metabolic complication burden in Chinese adolescents with obesity

Pediatric obesity presents with diverse metabolic phenotypes, yet the gut microbiota and metabolite signatures associated with obesity-related metabolic complications remain poorly defined. Here, we applied 16S rRNA gene sequencing and untargeted fecal metabolomics to investigate...

METTL3-mediated m6A modification of TP73-AS1 enhances HCC progression by activating Wnt/β-catenin signaling

Long noncoding RNAs (lncRNAs) play key roles in the onset and progression of hepatocellular carcinoma (HCC). Tumor protein 73 antisense RNA 1 (TP73-AS1), a recently identified lncRNA, has been implicated in cancer occurrence, drug resistance, and prognosis; however, its function...

Noninvasive 3D mapping of tissue stress using reverberant shear wave

Abstract Mechanical stress is a fundamental aspect of soft tissues that influences cellular behavior and tissue integrity, yet noninvasive imaging of stress in vivo remains a major challenge. Conventional magnetic resonance elastography (MRE) measures tissue stiffness but not str...

C-reactive protein–triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with H-type hypertension

Abstract Background The C-reactive protein–triglyceride glucose index (CTI) is a novel composite biomarker that integrates inflammation and insulin resistance. However, its association with the severity of coronary artery disease (CAD) in patients with H-type hypertension under d...

The association between sedentary behavior and eye diseases: a prospective study from the UK Biobank

Abstract Background Sedentary behavior (SB) is a well-established risk factor for multiple chronic diseases. However, evidence regarding its association with common ocular disorders remains limited and inconsistent. This study investigated the prospective associations between SB...