Tongde Hospital of Zhejiang Province

Genetically predicted circulating polyunsaturated fatty acids and Crohn’s disease susceptibility

Crohn disease (CD) remains an increasing global health burden. Omega-3 and omega-6 polyunsaturated fatty acids participate in lipid metabolism and inflammatory regulation, but previous observational and interventional studies have produced inconsistent findings. This study aimed...

The role of N6-methyladenosine (m6A) modification in the development and progression of head and neck squamous cell carcinoma (HNSCC): mechanistic insights and translational challenges

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent malignancy worldwide, encompassing tumors derived from the mucosal epithelia of the oral cavity, pharynx, larynx and other head and neck regions. Most patients are diagnosed at an advanced stage due t...

Intrinsic capacity, genetic susceptibility and incident inflammatory bowel disease: a prospective cohort study in UK Biobank

Abstract Inflammatory bowel disease (IBD) is a chronic immune-mediated disorder, but whether intrinsic capacity (IC), a multidomain measure of functional reserve, is associated with incident IBD remains unclear. We analysed 427,489 UK Biobank participants free of IBD at baseline...

LINC01419–miR-132-3p–USP38 axis mediates high glucose-induced ferroptosis in vascular endothelial cells

Abstract Long non-coding RNA LINC01419 has been implicated in ferroptosis in various pathological conditions, yet its role in type 2 diabetes mellitus (T2DM) associated vascular endothelial dysfunction remains unclear. This study investigated the mechanism by which LINC01419 modu...

Modulating the Gut‐Microbiota‐Brain Axis in Alzheimer's Disease: Therapeutic Potential of Nutritional and Metabolic Factors

ABSTRACT Background Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia among the elderly, characterized by a gradual decline in memory and cognitive function. The growing body of evidence highlighting the interaction between the...

Advances in the Diagnostic Evolution and Treatment of Atypical Lobular Endocervical Glandular Hyperplasia

Atypical lobular endocervical glandular hyperplasia (ALEGH) is a cervical precancerous lesion that develops independently of high-risk human papillomavirus (HPV) infection. It is regarded as a key intermediate stage in the progression from lobular endocervical glandular hyperplas...

An impaired excitatory-inhibitory balance in the right inferior temporal gyrus of patients with Alzheimer's disease correlated with executive function

Preliminary research indicates that an imbalance between excitation and inhibition may be an early pathological feature of Alzheimer's disease. However, the relevant brain networks, neurotransmitters and genetic mechanisms are still unclear. This study enrolled 27 patients with A...