Tokyo Women's Medical University Adachi Medical Center

Body Mass Index-Related Trends in Adverse Events with Enfortumab Vedotin: Analysis of a Pharmacovigilance Database and Medical Records

Abstract Background Enfortumab vedotin (EV) is an antibody–drug conjugate used to treat advanced urothelial carcinoma. Although EV therapy is effective, adverse events—particularly skin disorders—pose a challenge to optimal treatment. Previous reports suggest that body mass index...

Association between serum soluble (pro)renin receptor level and lower limb amputation in hemodialysis patients

Abstract Background The (pro)renin receptor [(P)RR] is a multifunctional protein, and its soluble form [s(P)RR], generated by proteolytic cleavage, has been proposed as a biomarker reflecting tissue renin–angiotensin system activity. Patients on maintenance hemodialysis (HD) have...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...