Tokyo Women's Medical University

Early improvement in depressive symptoms after pallidothalamic tract deep brain stimulation for drug-induced dystonia

Stimulation for lithium-induced dystoniaLong-term exposure to psychotropic agents, including lithium and dopamine D2/D3 partial agonists such as brexpiprazole, has been associated with delayed and sometimes persistent

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

Executive summary of the Japanese clinical practice guidelines for tuberous sclerosis complex-associated epilepsy 2025

Purpose Tuberous sclerosis complex (TSC)-associated epilepsy often involves focal epilepsy, infantile epileptic spasms syndrome (IESS), and drug-resistant epilepsy (DRE). This article presents an executive summary of the Japanese Clinical Practice Guidelines for Tuberous Sclerosi...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...

Clinical and molecular characteristics of thalamic gliomas in adults: prognostic impact of TERT promoter mutation

BACKGROUND: Adult thalamic gliomas (ATGs) are rare and biologically heterogeneous tumors. Although the 2021 World Health Organization (WHO) classification designates all diffuse midline gliomas (DMGs), H3-altered, as grade 4, accumulating evidence suggests that adult thalamic DMG...