Tokyo Women's Medical University

Surgical Timing in Relation to Visual Dysfunction in Skull Base Meningiomas Involving the Anterior Visual Pathway: A Propensity Score-Matched Analysis

Background/Objectives: Observation is generally recommended for asymptomatic meningiomas, but evidence from incidental meningiomas is derived largely from heterogeneous intracranial locations and may not directly apply to tumors involving the anterior visual pathway. We investiga...

Novel noninvasive technique for liver fibrosis evaluation using spatiotemporal analysis of strain elastography

Strain elastography is often limited by its relative nature and failure to capture temporal changes. This study aimed to establish a novel quantitative strain index (Q-SI) integrating spatiotemporal analysis and evaluate its utility for assessing liver fibrosis. This prospective...

Objective quantification of rectal transection technique using SureForm™ stapler log data in robotic rectal cancer surgery

Robotic surgical platforms continuously generate digital procedural data that may help assess surgical techniques. However, quantitative analyses of robotic stapler utilization during rectal transection remain limited. This study aimed to characterize rectal transection technique...

Healthcare burden and clinical spectrum of symptomatic polycystic liver disease in Japan: a nationwide epidemiological survey

Abstract Background Polycystic liver disease (PLD) is often asymptomatic, but some patients develop symptoms or complications requiring care or intervention. The nationwide burden of symptomatic PLD remains poorly defined. We conducted a nationwide survey to estimate the number a...

Perioperative determinants of post-induction blood pressure and prophylactic norepinephrine dose estimation in noncardiac surgery: a post hoc analysis of a prospective observational study

Post-induction hypotension is a common complication of general anesthesia and has been associated with adverse postoperative outcomes. We examined factors associated with post-induction minimum mean arterial pressure (MAP) and explored risk-profile–based model-derived norepinephr...

Association Between Acute-Phase Occupational Therapy and Quality of Life at Hospital Discharge and 90 Days After Discharge

Background/Objectives: Early rehabilitation in critically ill patients has been associated with improved physical outcomes. However, evidence regarding the association between occupational therapy and quality of life (QOL) remains limited. This study examined the association betw...

Implant size distribution and mid-term outcomes of transfibular total ankle arthroplasty in a Japanese cohort

Aims: Total ankle arthroplasty (TAA) is a widely accepted alternative to ankle arthrodesis for end-stage ankle arthritis. Preserving ankle motion is particularly relevant in Japanese populations, in which kneeling and squatting are integral to routine activities. However, Japanes...

Multiancestry genome-wide association and multiomics analyses elucidate spatiocellular features of multiple sclerosis genetics

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination disseminated in space and time. Here we performed a genome-wide association study (GWAS) using 688 MS cases and 205,199 controls from the Japanese population and...

Body Mass Index-Related Trends in Adverse Events with Enfortumab Vedotin: Analysis of a Pharmacovigilance Database and Medical Records

Abstract Background Enfortumab vedotin (EV) is an antibody–drug conjugate used to treat advanced urothelial carcinoma. Although EV therapy is effective, adverse events—particularly skin disorders—pose a challenge to optimal treatment. Previous reports suggest that body mass index...

Association between serum soluble (pro)renin receptor level and lower limb amputation in hemodialysis patients

Abstract Background The (pro)renin receptor [(P)RR] is a multifunctional protein, and its soluble form [s(P)RR], generated by proteolytic cleavage, has been proposed as a biomarker reflecting tissue renin–angiotensin system activity. Patients on maintenance hemodialysis (HD) have...

Dual-tracer 18F-FDG and 18F-FLT PET/CT for differentiating metastatic lymph nodes from sarcoid involvement in a patient with vulvar squamous cell carcinoma and coexisting pulmonary sarcoidosis

Differentiating sarcoidosis lesions from metastatic lymph nodes is a well-known clinical challenge, particularly in patients with malignancy in whom sarcoid lesions may mimic nodal metastases on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG P...

Response to “Sample Representativeness and Test–Retest Reliability in the Japanese Everyday Ageism Scale: A Methodological Reconsideration”

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

De-escalation of perioperative systemic therapy for early breast cancer.

Breast cancer is the most common malignancy among women worldwide, and the number of survivors continues to increase owing to earlier detection and advances in treatment. As long-term survivorship becomes increasingly important, minimizing treatment-related toxicity without compr...

Early improvement in depressive symptoms after pallidothalamic tract deep brain stimulation for drug-induced dystonia

Stimulation for lithium-induced dystoniaLong-term exposure to psychotropic agents, including lithium and dopamine D2/D3 partial agonists such as brexpiprazole, has been associated with delayed and sometimes persistent

Executive summary of the Japanese clinical practice guidelines for tuberous sclerosis complex-associated epilepsy 2025

Purpose Tuberous sclerosis complex (TSC)-associated epilepsy often involves focal epilepsy, infantile epileptic spasms syndrome (IESS), and drug-resistant epilepsy (DRE). This article presents an executive summary of the Japanese Clinical Practice Guidelines for Tuberous Sclerosi...

Clinical and molecular characteristics of thalamic gliomas in adults: prognostic impact of TERT promoter mutation

BACKGROUND: Adult thalamic gliomas (ATGs) are rare and biologically heterogeneous tumors. Although the 2021 World Health Organization (WHO) classification designates all diffuse midline gliomas (DMGs), H3-altered, as grade 4, accumulating evidence suggests that adult thalamic DMG...

The Clinicopathological Characteristics and Prognosis of Cholangiolocarcinoma: A Multicenter Study With a Central Pathology Review

BACKGROUND: Cholangiolocarcinoma (CLC) is a rare liver cancer with ≥ 80% ductular configuration (DC). Given its rarity, its clinicopathological characteristics remain poorly understood, and its status as a distinct disease entity remains controversial. We conducted a nationwide m...