Tokyo University of Pharmacy and Life Sciences

Contrasting Cannabinoid Receptor 2 (CB2R)-Associated Responses in Two Different Cerebrovascular Endothelial Cell Lines in a Blood Brain Barrier Model in the Context of HIV

Despite the success of suppressive antiretrovirals, infection with human immunodeficiency virus (HIV) is associated with several comorbidities which include negative consequences to the central nervous system (CNS), where disruption of the blood-brain barrier (BBB) is a major und...

A case of renal hypouricemia type 1 associated with compound heterozygous URAT1/SLC22A12 variants A209V and F379L: clinical evidence for their pathogenic significance

Abstract Renal hypouricemia (RHUC) is an inherited renal tubular disorder characterized by low serum uric acid levels and excessive urinary uric acid excretion due to impaired urate reabsorption in proximal tubules. Type 1 RHUC (RHUC1) is caused by pathogenic variants in URAT1/SL...

Isocoumarin Ring Rearrangement Approach to π-Extended Dibenzothiophenes

Sulfur-functionalized isocoumarins have been successfully converted into 1,2,3,4-tetrasubstituted naphthalenes through the addition of ketene silyl acetals and the subsequent skeletal rearrangement triggered by fluoride. The densely and consecutively substituted structures of the...

Epithelial integration in tissue-engineered oral mucosa using RGDTFI-presenting micropatterned collagen scaffolds

Objective To determine whether presentation of the integrin αvβ3/αvβ5-binding peptide motif RGDTFI on micropatterned collagen scaffolds improves epithelial coverage and stabilizes the epithelial–scaffold interface during fabrication of tissue-engineered oral mucosa (TEOM). Method...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

A genotype-first approach reveals the molecular basis of pyrin inflammasome activation

Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classified as variants of uncertain significanc...