Tokyo National Hospital

A study to learn how well HER3-DXd (patritumab deruxtecan) works and how safe it is in people with previously treated non-small-cell lung cancer that has a mutation in the EGFR gene: a plain language summary of the HERTHENA-Lung01 study

Plain Language SummaryWhat is this summary about?This is a summary of the publication about the HERTHENA-Lung01 study, which was published in the Journal of Clinical Oncology in September 2023. The study included 277 adults with non-small-cell lung cancer (NSCLC) that had a mutat...

Volume‐based stereotactic radiofrequency thermocoagulation for focal cortical dysplasia: A potentially safer alternative to resection in insulo‐opercular and central regions

Abstract Objective Deep white matter infarction caused by injury to the medullary arteries is a crucial cause of postoperative neurological deficits following surgical resection of focal cortical dysplasia (FCD) in the central and insulo‐opercular cortices. Volume‐based radiofreq...

Comprehensive Genomic Profiling Beyond Driver Testing in Non‐Squamous Non‐Small Cell Lung Cancer With Known Drivers

In advanced non-squamous non-small cell lung cancer (non-sq NSCLC), companion diagnostic testing (CDx) identifies actionable driver alterations and guides initial targeted therapy. However, disease progression inevitably occurs through acquired resistance, including activation of...

Comparison between Janus kinase inhibitor monotherapy and combination therapy with methotrexate in patients with rheumatoid arthritis: insight from the National Database of Rheumatic Diseases in Japan (NinJa) registry

Abstract Background: Janus kinase inhibitors (JAKi) are effective for rheumatoid arthritis (RA) and can be used as monotherapy; however, the clinical benefit of concomitant methotrexate (MTX) and the optimal MTX dose in JAKi-treated patients remain unclear in real-world settings....

Early administration of calcineurin inhibitors limits tolerogenic effect of PTCy in allogeneic hematopoietic transplant

We recently demonstrated early administration of calcineurin inhibitors (CNIs) after murine allogeneic hematopoietic cell transplantation (allo-HCT) inhibits terminal exhaustion of donor T cells and hampers tolerance induction. However, the role of CNIs in regulating T-cell exhau...

P1.084. Exploring the Role of Adjuvant Nivolumab After Neoadjuvant FLOT Followed by Surgery in Resectable ESCC: Implications for Cisplatin-Unfit Patients

Abstract Topic Esophageal Cancer: Adjuvant and Neo-Adjuvant Therapies Background In Western countries, neoadjuvant chemoradiotherapy (CRT) is standard, and CheckMate 577 showed adjuvant nivolumab prolonged disease free survival (DFS) with non-pathological complete response (non-p...