Tokyo Metropolitan Komaba High School

Sequentially Self-Assembled Supramolecular Nanocomplexes Enable Systemic Cas9 RNP Delivery and In Vivo Tumor Genome Editing

In vivo genome editing utilizing Cas9/sgRNA ribonucleoproteins (RNPs) holds substantial therapeutic promise, yet rapid bloodstream clearance and degradation of RNPs have hindered its accumulation within the target site and effective gene editing. Herein, we report a supramolecula...

Origin of Regioselectivity in C–H Bond Scission by Radicals: Quantitatively Predicting Effect of Electrophilicity Using Adamantane

Abstract Hydrogen abstraction is a key step in the oxidation of saturated hydrocarbons and the functionalization of C–H groups via hydrogen atom transfer. To evaluate and predict the regioselectivity of active species in these reactions, adamantane has long been utilized as a pro...

Beyond Intrinsic Oxidation Activity: Charge-Distributed Reaction Fields in Polyoxometalate-Based Porous Ionic Crystals

Abstract Molecular catalysts assembled into solids can exhibit catalytic properties beyond those of their individual components, yet the origin of this enhancement is often unclear. Here, we address this issue using porous ionic crystals (PICs) based on polyoxometalates (POMs). T...

Upcycling waste concrete powder into cement-free construction materials through low-dosage micron-sized polyethylene and hot-pressing

Massive quantities of concrete waste and polyethylene (PE) waste are generated annually, yet both remain underutilized. Previous studies showed that carbonation-induced CaCO 3 crystal bridges enhanced interparticle bonding and strength of compacted recycled concrete material, but...

Cryogenic time-division-multiplexed voltage control for scalable trapped-ion quantum processors

Trapped-ion quantum computers based on the quantum charge-coupled device architecture require on the order of ten trap electrodes per qubit, making the number of vacuum feedthroughs a bottleneck at the system scale. Time-division multiplexed (TDM)-based voltage control for trap e...