Tokyo Metropolitan Institute of Gerontology

Prion-like transmission of human tau strains in the mouse brain

Abstract Most neurodegenerative diseases are thought to spread through the brain by prion-like mechanisms, in which filamentous protein assemblies self-propagate by templated seeding 1 . Distinct conformations of amyloid filaments may provide the physical basis for the strains th...

Association between central sensitization symptoms and cold hypersensitivity severity in older adults: a cross-sectional analysis from the Otassha Study

Abstract Introduction: Cold hypersensitivity (Hie) is a common complaint among older adults in East Asia and has traditionally been attributed to peripheral circulatory dysfunction. However, emerging evidence suggests that central sensitization (CS) may also contribute. This stud...

Feasibility and effects of a multicomponent program incorporating esports on physical and cognitive function among older adults: A non-randomised pilot trial

Background Esports (competitive and organised video gaming) may enhance physical and cognitive health in older adults. The aim of this study was to examine the feasibility and effects of a multicomponent program incorporating esports on physical and cognitive function in communit...

24-hour movement behaviour patterns differ across depressive symptom trajectories in community-dwelling older adults: a group-based trajectory model and compositional data analysis

Depressive symptoms in older adults change over time and do not follow a single uniform pattern. Whether 24-hour movement behaviour composition differs across depressive symptom trajectories remains unclear. This longitudinal secondary analysis used data from the Survey of Health...

Association Between Oral Frailty and Body Mass Index in Late-Stage Older Adults Stratified by Sarcopenia Status

Objectives: Oral frailty is associated with sarcopenia and underweight; however, its relationship with sarcopenic obesity remains unclear. This cross-sectional study investigated the associations between oral frailty and body mass index (BMI) categories (underweight/obesity), str...

SYK inhibitor fostamatinib promotes mitochondrial respiratory chain supercomplex formation and improves skeletal muscle function in aged mice

Mitochondria are major organelles involved in energy metabolism and play a crucial role in the function of muscular tissues. Mitochondrial respiratory chain (MRC) complexes are assembled to higher-order “MRC supercomplex (SC)” structures, which has been suggested to promote energ...

P1.114. Endoscopic Diagnosis of Esophageal Cancer Using Ultra-High Magnification Endocytoscopy

Abstract Topic Esophageal Cancer: New Diagnostic Modalities (Including PET, PET-CT, New Tracers) Background Background Ultra-high magnification endoscopic observation using endocytoscopy (EC) enables cellular-level visualization and allows in vivo assessment comparable to histopa...