Tokyo Medical and Dental University

A skeletal–smooth muscle interface mediates levator ani attachment to the rectum and vagina: a macroscopic and histological study

Abstract We aimed to clarify the attachment architecture between the levator ani and the rectum and vagina using integrated macroscopic and histological analyses of human pelvic floor specimens. Macroscopic dissection consistently demonstrated whitish soft tissue at the interface...

Spatial variation in neurological outcomes after shockable out-of-hospital cardiac arrest in central Tokyo: a single-center retrospective study

In urban areas, abundant medical resources improve outcomes for patients with out-of-hospital cardiac arrest (OHCA). However, metropolitan environments present unique pre-hospital transportation challenges rarely observed in rural areas, such as complex transportation networks an...

Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey

<title>Abstract</title> Background Gender equity, work–life balance, and career development have become important concerns in the medical profession. However, empirical evidence on how neuro-oncology professionals experience working conditions, career barriers, and perceived ineq...

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Fetal cardiomyocytes in the human heart are diploid and proli...

Serum periostin levels in myocardial infarction: Findings from forensic autopsy cases

Acute myocardial infarction (AMI) remains one of the leading causes of sudden death with significant implications in both clinical and forensic practice. In forensic settings, AMI diagnosis traditionally relies on gross and histopathological findings. However, when ischemic chang...

Generation of a senescent synovial organoid model using rat synovial fibroblasts treated with oxidative stress

Abstract Background Osteoarthritis (OA) is a common age-related joint disease characterized by cartilage loss and synovitis. Cellular senescence contributes to chronic inflammation through senescence-associated secretory phenotypes (SASPs). Recent evidence indicates that senescen...

A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-metho...