Tokyo Medical and Dental University

Suicide attempt methods among patients referred for psychiatric evaluation at an advanced emergency and critical care medical center in Japan: associations with sex, age, and psychiatric diagnosis: a single-center retrospective study

Suicide attempts requiring emergency care provide a critical opportunity for psychiatric assessment and prevention. However, contemporary evidence from advanced emergency settings remains limited, particularly regarding how suicide attempt methods vary according to sex, age, and...

Neurodevelopmental Trait Subgroups in Medically Unexplained Oral Symptoms: A Retrospective Observational Study

Introduction and aims Medically unexplained oral symptoms (MUOS) are heterogeneous conditions with prominent subjective complaints despite limited objective findings. We examined whether autism spectrum disorder (ASD)- and attention-deficit/hyperactivity disorder (ADHD)-related t...

Exploratory analysis of IFN-α-high and CXCL9-high cytokine distributions in systemic lupus erythematosus-associated macrophage activation syndrome

Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory complication of systemic lupus erythematosus (SLE), but its immunopathology remains poorly understood. We investigated cytokine-associated inflammatory heterogeneity in SLE-associated MAS (SLE-MAS). Seru...

Influence of axial motion amplitude on stress generation, canal-centering ability, and motor-recorded torque during XP-endo Shaper instrumentation: an in vitro study

The optimal axial motion amplitude during nickel-titanium rotary canal instrumentation has not yet been fully clarified. To evaluate the effects of axial motion amplitude on shaping behavior and motor-recorded torque during root canal instrumentation using the XP-endo Shaper (XPS...

Effect of tooth preparation design on fracture load and fracture behavior of deciduous crowns fabricated by subtractive and additive manufacturing

Abstract Objectives This study evaluated the effects of crown material and margin design on fracture load and behavior of computer-aided design/computer-aided manufacturing (CAD-CAM) crowns for deciduous molars. Methods Three subtractive-manufacturing (SM) materials and two addit...

Distinct fascicular and epineurial architecture of the obturator nerve: a comparative analysis with clinical and surgical relevance

Peripheral nerves of the lumbar plexus share a common origin but exhibit distinct anatomical and clinical features.Although the gross anatomy of these nerves has been described, differences in cross-sectional structure remain unclear.This study compared the histological architect...

Differential efficacy and safety of ruxolitinib in primary versus secondary hemophagocytic lymphohistiocytosis: a systematic review and meta-analysis

Ruxolitinib (RUX), a JAK1/JAK2 inhibitor, has demonstrated therapeutic potential in both primary and secondary hemophagocytic lymphohistiocytosis (pHLH & sHLH), but quantitative evidence comparing its efficacy and safety across subtypes remains lacking. Given the absence of rando...

Exploratory spatial transcriptomic analysis of compartment-specific recurrence-associated gene expression in gastric cancer

We hypothesized that the prognostic value of immune and stromal gene expression is spatially dependent—specifically, signals driving homeostasis in the superficial mucosa may differ functionally from those at the deep invasive front. We analyzed formalin-fixed paraffin-embedded s...

Development of the nasal capsule in Emydura subglobosa (Testudines: Pleurodira) with a comparison to other turtles

Abstract Extant turtles occupy freshwater, marine, and terrestrial habitats, and their nasal region provides important evidence for the evolution of respiration‐ and sensory‐related cranial morphology. However, developmental data on the turtle nasal capsule remain limited, partic...

Long Intramural Left Coronary Artery Confined to the Left Sinus of Valsalva with Diastolic Deformation: A Case Report

Abstract Background Anomalous aortic origin of a coronary artery (AAOCA) is a rare congenital anomaly. The most frequently reported and surgically treated form involves origin of a coronary artery from the opposite sinus that follows an interarterial course, often termed “maligna...

Podocyte injury damages podocytes in chimeric organoids

Abstract We have previously shown that injury to a subset of podocytes can trigger secondary damage in neighboring podocytes, but whether this phenomenon depends on direct intercellular interaction is unknown. To address this, kidney organoids were generated from nephron progenit...

A skeletal–smooth muscle interface mediates levator ani attachment to the rectum and vagina: a macroscopic and histological study

Abstract We aimed to clarify the attachment architecture between the levator ani and the rectum and vagina using integrated macroscopic and histological analyses of human pelvic floor specimens. Macroscopic dissection consistently demonstrated whitish soft tissue at the interface...

Spatial variation in neurological outcomes after shockable out-of-hospital cardiac arrest in central Tokyo: a single-center retrospective study

In urban areas, abundant medical resources improve outcomes for patients with out-of-hospital cardiac arrest (OHCA). However, metropolitan environments present unique pre-hospital transportation challenges rarely observed in rural areas, such as complex transportation networks an...

Working conditions, career barriers and perceived equity among neuro-oncology professionals: insights from the Japan society for neuro-oncology (JSNO) gender equality and diversity committee survey

<title>Abstract</title> Background Gender equity, work–life balance, and career development have become important concerns in the medical profession. However, empirical evidence on how neuro-oncology professionals experience working conditions, career barriers, and perceived ineq...

Serum periostin levels in myocardial infarction: Findings from forensic autopsy cases

Acute myocardial infarction (AMI) remains one of the leading causes of sudden death with significant implications in both clinical and forensic practice. In forensic settings, AMI diagnosis traditionally relies on gross and histopathological findings. However, when ischemic chang...

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Fetal cardiomyocytes in the human heart are diploid and proli...

Generation of a senescent synovial organoid model using rat synovial fibroblasts treated with oxidative stress

Abstract Background Osteoarthritis (OA) is a common age-related joint disease characterized by cartilage loss and synovitis. Cellular senescence contributes to chronic inflammation through senescence-associated secretory phenotypes (SASPs). Recent evidence indicates that senescen...

A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-metho...