Tokushima University

Skin toxicity and effectiveness of first-line enfortumab vedotin plus pembrolizumab for urothelial carcinoma: a prospective multicenter real-world study in Japan

Background Skin toxicity is a common adverse event associated with enfortumab vedotin plus pembrolizumab (EVP) but its association with treatment outcomes remains unclear. We aimed to evaluate this association in patients with locally advanced or metastatic urothelial carcinoma (...

Seismic and tsunami hazard potential of the Negros–Sulu megathrust, Philippines

Abstract. The Negros–Sulu megathrust poses an imminent threat to coastal communities surrounding the Sulu Sea, but with limited information on past tsunamis, megathrust geometry, and locked segments, robust seismic and tsunami hazard assessments are hindered. To identify highly e...

Developing a Comprehensive Public Health Nursing Practice Model for Promoting Social Inclusion Among Populations Experiencing Social Exclusion: A Qualitative Study

ABSTRACT Aims To develop a comprehensive practice model delineating public health nursing practices that promote social inclusion and illustrate their outcomes in Japan. Design Qualitative descriptive research design. Methods Semi‐structured interviews were conducted with 12 publ...

Sexually dimorphic control of excitatory synapse maintenance in ventral hippocampal circuits by Neurexin2α ligand Vstm2b

Abstract Neuronal networks rely on precise synapse formation, maturation, and maintenance orchestrated by synaptic adhesion molecules including α- and β-neurexins (Nrxns). Through unbiased proteomics, we identified Vstm2 family members as α-Nrxn-specific interactors that require...

Computed tomography findings of a retroperitoneal chronic expanding hematoma with multiple hemangiomas: A case report and literature review

Chronic expanding hematoma (CEH) is an uncommon lesion that gradually increases in size over time. A hemangioma is a benign vascular tumor that may involve the skin, mucosa, or visceral organs; however, involvement of retroperitoneal organs is rare. Herein, we describe the case o...

Astrocytic cathepsin D promotes α-synuclein processing and Lewy neurite-like aggregate maturation

Abstract Parkinson’s disease (PD) and related synucleinopathies are marked by the accumulation and propagation of α-synuclein (α-syn) aggregates, a process primarily studied in neurons. Whether astrocytes actively contribute to α-syn processing and intercellular transfer remains...

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a conventional observational and two‐sample Mendelian randomization (MR) study in the same population (triangulation). We followed 13,695 individuals aged 35–69 years for cancer...

Immediate Changes in Perceived Person-Centered Care and Technological Competency Following a One-Day Collective Training Program Among Mongolian Nurse Managers and Nurses Nominated for Managerial Roles: A Pilot Pre–Post Study

Background/Objectives: Person-centered care (PCC) and the Technological Competency as Caring in Nursing (TCCN) theory are increasingly emphasized in nursing leadership, but no published study has evaluated a PCC/TCCN training program among Mongolian nurse managers. This uncontrol...

Procedure-Specific Postoperative Drainage Strategy in Transforaminal Full-Endoscopic Spine Surgery: A Quantitative Evaluation of Drain Output and Endoscopic Bleeding Findings

Background Postoperative drain use after transforaminal full-endoscopic spine surgery (TF-FESS) remains controversial, and procedure-specific criteria are not well defined. This study aimed to determine whether postoperative bleeding risk—quantified by postoperative drain output...

Technology-Supported Japanese Learning in Pre-Departure Migration Preparation: Learning Challenges and Digital Practices Among Vietnam’s Japan-Bound Technical Intern Trainees

Technical intern trainees (TITs) preparing to depart for Japan study Japanese within a compressed four- to six-month pre-departure period, during which they must acquire language skills for workplace communication, daily life, and social adaptation. This cross-sectional study exa...

Chronic stress disrupts the network among stress granules, P-bodies, and motor proteins

Stress granules (SGs) are dynamic RNA condensates that assemble rapidly in response to cellular stress following translational arrest, thereby promoting adaptation and influencing disease pathogenesis. Although SG assembly and disassembly during acute stress have been extensively...

Direct composite injection molding with bilayered three-dimensional-printed clear index: a fully digital workflow case report of post-orthodontic anterior tooth wear

Background Recently, a new generation of high-strength flowable dental composites has been introduced by manufacturers.The manufacturers claim that these materials have enhanced mechanical and physical properties and are suitable for use in a wide range of direct anterior and pos...

Comparative in vivo evaluation of colistin resistance determinants in Escherichia coli clone ST131

Background Colistin is a last-resort antimicrobial for multidrug-resistant (MDR) Gram-negative infections. Health risks associated with colistin resistance are commonly inferred from resistance phenotypes, despite limited in vivo evidence linking resistance determinants to pathog...