Institution
Tisch Hospital
Recent research
- Health & MedicineOpen access
Traditional weight-based dosing results in variable rabbit anti-thymocyte globulin (rATG) clearance, delaying CD4+Tcell-immune-reconstitution (CD4 + IR) and impacting outcomes. In a retrospective pharmacokinetic/pharmacodynamic analysis of patients undergoing first T-replete hema...
- Health & MedicineOpen access
Reappraisal of Cisplatin vs Carboplatin Treatment for Solid Tumors
Importance Cisplatin and carboplatin are central pillars of chemotherapy in solid tumor oncology, but their comparative efficacy and tolerability remain variably defined in the literature across tumor types and settings. Objective To quantify and grade the certainty of evidence c...
- BiologyOpen access
Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma
There is limited understanding of the epigenetic drivers of tumor evolution in hepatocellular carcinoma (HCC). Here we characterize the epigenetic contribution of methylation to intra-tumoral heterogeneity (mITH) using regional enhanced reduced-representation bisulfite sequencing...
- Health & MedicineOpen access
PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...
- Health & MedicineOpen access
Reliability of a Home-Based Smartphone Balance Assessment in Healthy Middle-Aged and Older Adults
Smartphone accelerometry could enable longitudinal home-based balance testing, yet its reliability across tasks and outcome measures must be established. We assessed the test–retest reliability and measurement precision of a custom smartphone balance application. Sixty-nine healt...