Tianjin Medical University General Hospital

Commensal Lachnospiraceae bacterium mitigates colitis-induced mucin fucosylation deficits through ILC3/IL-22 axis

Flagellins from commensal bacteria are potent modulators of intestinal immunity, yet their strain-specific functions, particularly in promoting homeostasis in ulcerative colitis (UC), remain poorly defined. We investigate whether flagellin from the commensal Lachnospiraceae bacte...

Prognostic Evaluation of Acute Ischemic Stroke Patients After Mechanical Thrombectomy Incorporating Imaging, Inflammatory, and Rehabilitation Aspects

AIM: We aimed to perform a prognostic evaluation for patients with acute ischemic stroke after mechanical thrombectomy (MT) incorporating imaging, inflammatory, and rehabilitation aspects.METHODS: A retrospective cohort analysis of patients with acute ischemic stroke (AIS) after...

Regional Adipose Distribution Reveals Differential Genetic Risk Patterns for Cardiometabolic Diseases

Background Cardiometabolic risk associated with obesity is increasingly recognized to be strongly influenced by the anatomical distribution and ectopic deposition of adipose tissue, yet the genetic mechanisms linking adipose depots to cardiometabolic diseases remain incompletely...

HIF1α-dependent GGT5 expression promotes gastric cancer progression under hypoxia

The hypoxic tumor microenvironment fosters rapid growth and metastasis of carcinomas. Glutathione (GSH) plays a pivotal role in tumor metabolism. Understanding the mechanisms underlying GSH metabolism, including the role of hypoxia-inducible factor 1-alpha (HIF1α) in gastric canc...

Coniferaldehyde Reverses PGK1–3-Phosphoglycerate–L-Serine Metabolic Reprogramming in Hindlimb Ischemia

Background/Objectives: Ischemic skeletal muscle undergoes metabolic remodeling that may influence vascular repair. We investigated whether coniferaldehyde (CA) regulates a phosphoglycerate kinase 1 (PGK1)–3-phosphoglycerate (3PG)–L-serine axis in mouse hindlimb ischemia (HLI). Me...

Association between respiratory phenotypes and successful ventilator liberation in early-onset and late-onset ARDS: a multicenter cohort study

Early-onset and late-onset acute respiratory distress syndrome (ARDS) differ in clinical course and outcomes, but their longitudinal respiratory trajectories remain unclear. We aimed to characterize respiratory trajectories in early- and late-onset ARDS and identify trajectory-ba...

Increased gamma oscillations and inter-regional brain asymmetry associated with sepsis-associated delirium: a prospective cohort study

Sepsis-associated delirium (SAD) is thought to involve disrupted functional brain network connectivity. The aim of this study was to characterize the electroencephalographic (EEG) features of SAD and to develop a predictive model based on these features. Of 98 eligible patients w...

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

Insights into Shared Genetic Architecture Linking Thyroid Function and Cancer

Abstract Background Growing evidence suggests a complex interplay between thyroid function and various cancers, and yet their shared genetic basis and underlying mechanisms remain unclear. Methods This study leveraged large-scale genome-wide association study (GWAS) summary for f...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Prevalence of functional constipation in Asian children and adolescents: a systematic review and meta-analysis of cross-sectional studies

Functional constipation (FC) is a common pediatric disorder, though synthesized prevalence data specific to Asian children remain limited. This meta-analysis aimed to estimate the pooled prevalence of FC among Asian children and adolescents and explore sources of heterogeneity. W...

Texture similarity network uncover schizophrenia subtypes with unique molecular signatures

Abstract Schizophrenia manifests complex heterogeneity across multiple dimensions, posing major challenges for precise diagnosis and treatment. Developing objective biomarkers to stratify patients into stable subtypes is essential for heterogeneity resolving and precision medicin...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Distal-first versus proximal-first laparoscopic nephroureterectomy for non-muscle-invasive upper tract urothelial carcinoma: a retrospective cohort study

Abstract Background and objective The optimal sequence of ureteral and vascular control during laparoscopic nephroureterectomy (LNU) for non-muscle-invasive (≤ pT1) upper tract urothelial carcinoma (UTUC) remains controversial. We compared distal-first (initial ureteral ligation)...

Long-term outcomes of capsular tension ring implantation during phacoemulsification with intraocular lens implantation combined with trabeculectomy in acute angle-closure crisis

To evaluate the 3-year efficacy and safety of capsular tension ring (CTR) implantation during phacoemulsification with intraocular lens implantation (PEI) combined with trabeculectomy (Trab) in patients with acute angle-closure crisis (AACC). Retrospective cohort study. Patients...

Exercise-specific mechanical stimuli are associated with regional lumbar bone adaptation: a combined in vivo and in silico multi-scale study

Abstract Background Exercise is widely recommended to maintain lumbar bone mineral density (BMD), the tissue-level mechanical environment generated within the lumbar spine during different exercises remains difficult to assess in vivo. This study integrated individualized musculo...

Gut microbiota‑driven indole‑3‑propionic acid protects against sepsis‑associated encephalopathy via inhibiting BNIP3L ubiquitination and restoring BNIP3L‑dependent mitophagy as a potential molecular mechanism

Sepsis-associated encephalopathy (SAE) is a severe refractory neurological complication occurring in up to 70% sepsis patients with no targeted therapies. Gut microbiota-derived indole-3-propionic acid (IPA), a tryptophan metabolite, exerts neuroprotective effects, but its therap...

DNASE1L3 as a prognostic biomarker associated with immune cell infiltration in pancreatic cancer

Pancreatic adenocarcinoma (PAAD) is a highly aggressive malignancy, associated with a poor prognosis and a five-year survival rate of less than 9%. Although DNASE1L3 is known as an apoptosis-related gene, its specific role in cancer remains unclear. This study aimed to investigat...

Multiple-adverse health conditions, mental health, and health-related quality of life in stroke survivors: Latent profile analysis and mediation analysis

Objective This study aimed to identify subgroups of stroke survivors based on multiple-adverse health conditions and determine the potential mediation effects of mental health in their relationship with health-related quality of life. Design A cross-sectional study. Setting Three...

Evaluating the PIRAA mechanism in undergraduate gerontological nursing: effects on knowledge, attitudes, and self-rated competencies

Abstract Background Rapid population aging challenges health-care systems and underscores the need for educational models that build gerontological competencies in nursing students. The Policy–Industry–Research–Application–Academic (PIRAA) mechanism is a multifaceted pedagogical...