Tianjin Medical University General Hospital

Multiple-adverse health conditions, mental health, and health-related quality of life in stroke survivors: Latent profile analysis and mediation analysis

Objective This study aimed to identify subgroups of stroke survivors based on multiple-adverse health conditions and determine the potential mediation effects of mental health in their relationship with health-related quality of life. Design A cross-sectional study. Setting Three...

Evaluating the PIRAA mechanism in undergraduate gerontological nursing: effects on knowledge, attitudes, and self-rated competencies

Abstract Background Rapid population aging challenges health-care systems and underscores the need for educational models that build gerontological competencies in nursing students. The Policy–Industry–Research–Application–Academic (PIRAA) mechanism is a multifaceted pedagogical...

Perioperative recovery and survival after lobectomy versus sublobar resection in adults aged ≥ 70 years with NSCLC ≤ 3 cm: complementary SEER and real-world cohort analyses

For older adults with non-small cell lung cancer (NSCLC), the choice of resection must balance durable cancer control against physiological reserve and postoperative recovery. We combined population-level long-term survival data with granular real-world perioperative data to exam...

P2RY13-Negative Tumor-Associated Macrophages Promote NETosis and Are Associated with Poor Prognosis Across Multiple Cancers

Background: Neutrophil extracellular traps (NETs) promote tumor progression and immune evasion across multiple cancers. However, the mechanisms governing NET formation (NETosis) within the tumor immune microenvironment remain incompletely understood. Low P2RY13 expression is asso...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...