Tianjin Medical University Eye Hospital

Impact of oculorespiratory reflex on postoperative recovery following pediatric strabismus surgery: a retrospective cohort study

The Oculorespiratory Reflex (ORR) is a common intraoperative reflex observed in pediatric patients undergoing strabismus surgery. Despite its prevalence, the potential association between ORR and postoperative complications has not been thoroughly investigated. This retrospective...

Novel mutations of PIKFYVE identified in 322 sporadic cataract patients

BACKGROUND: PIKFYVE, a novel pathogenic gene causing congenital cataract, its association with sporadic cataracts has not been systematically investigated. This study aimed to explore PIKFYVE mutation profiles in major sporadic cataract subtypes. METHODS: We enrolled 322 sporadic...

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Local flow patterns determine the uneven distribution of atherosclerotic lesions, yet the underlying mechanism remains poorly defined. We previously reported that protein tyrosine phosphatase nonreceptor type 14 (PTPN14) is implicated in atherosclerosis. Its role in flow-dependen...

Blue Light Pollution and Ocular Surface Toxicity: p53-Mediated Ferroptosis in Corneal Epithelium Drives Dry Eye Pathogenesis

Purpose: This study investigated the molecular mechanisms underlying blue light-induced corneal epithelial toxicity. Methods: C57BL/6J mice were exposed to 460 nm blue light for 1, 2, or 4 weeks, whereas human corneal epithelial (HCE) cells were exposed for 15 or 30 min. RNA-sequ...

Selective compartmental plication in small-angle convergence insufficiency exotropia: surgical outcomes and predictive model

This study aimed to evaluate a novel surgical approach combining unilateral lateral rectus recession (LRc) with compartmentalized inferior medial rectus plication (CIMRP) for treating small-angle (< 25 prism diopters, PD) convergence insufficiency intermittent exotropia (CI-IXT)...