Tianjin Medical University Cancer Institute and Hospital

Systematic analysis reveals that KCNH8 suppresses triple-negative breast cancer progression through PI3K‑AKT inhibition

Among women, tripple-negative breast cancer (TNBC) is highly prevalent, and controlling recurrence and metastatic disease remains difficult in clinical practice. The potassium channel KCNH8 shows dysregulated expression across multiple cancers; however, its roles and underlying m...

Single-Cell and Spatial Transcriptomics Reveal CHCHD3 as a Therapeutic Target to Activate cGAS-STING and Overcome Immunosuppression in Lung Adenocarcinoma

Abstract A substantial proportion of treatment-naive lung adenocarcinoma (LUAD) patients exhibit intrinsic resistance to neoadjuvant chemoimmunotherapy, highlighting the need for mechanism-driven therapeutic strategies. Here, we performed integrated single-cell RNA sequencing (sc...

Single-cell and bulk transcriptomic integration identifies a high-CNV, dark-zone-enriched malignant cell state associated with adverse prognosis in GCB-DLBCL

Background Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) generally has a better prognosis than activated B-cell-like DLBCL, yet a clinically significant subset of patients still develops aggressive disease, suggesting marked malignant cellular heterogeneit...

Targeting USP14 disrupts lipid metabolism and survival pathways in diffuse large B-cell lymphoma (DLBCL)

Abstract Proteasome inhibitors have transformed cancer therapy in certain settings. However, their overall effectiveness is often limited as residual proteasome function is retained through the overexpression of ubiquitin-specific protease 14 (USP14), a proteasome-associated deub...

Influencing Factors of Prognosis in Adjuvant Trastuzumab Therapy for HER2-Positive Breast Cancer

/HER2) positive breast cancer receiving adjuvant trastuzumab therapy. Additionally, a stratified assessment will be conducted based on the hormone receptor (HR) status; thereby providing a practical basis for clinical treatment.MethodA total of 643 patients with HER2-positive bre...

Single-cell landscape reveals PLPP2 upregulation underlying radiotherapy resistance and immune microenvironment remodeling in pancreatic cancer

The main purpose of this study was to investigate the molecular mechanisms underlying radiotherapy resistance in pancreatic cancer by integrating single-cell transcriptomic analysis with multicenter clinical cohorts. Using machine learning algorithms and genomic data, we identifi...

Macrophage-mimetic liposomal nanovesicles deliver CXCR2 antagonists to suppress CXCL2-driven breast cancer and atherosclerotic progression

The coexistence of breast cancer (BC) and atherosclerosis (AS) is increasingly recognized as an inflammation-driven comorbidity. This study identifies the CXCL2–CXCR2 signaling axis as a pivotal mechanistic link underlying both diseases and introduces a macrophage-mimetic nanopla...

Naphthalimide-based andrographolide nanoplatform suppresses ccRCC via targeting the HIF-2α/VEGF signaling axis

Constitutive activation of hypoxia-inducible factor-2α (HIF-2α) is a central oncogenic driver in clear cell renal cell carcinoma (ccRCC). In this work, a naphthalimide-based multifunctional nanoplatform was developed as a drug delivery system for andrographolide (AG) to improve i...

SelO functions as a tumor suppressor through AMPylating Cdk5rap3

Cell fate is governed by signaling pathways involving diverse protein modifications. However, how protein AMPylation mediates signal transduction in mammalian cells remains largely unexplored. We demonstrate that the protein adenylyltransferase, SELENOO (SelO), is induced by chem...

Dynamic multi-priority admission scheduling for multimorbid patients: an MDP approach incorporating balking penalties

Efficient admission scheduling for multimorbid patients remains a critical challenge in hospital operations, particularly in mitigating patient balking behavior caused by bed shortages. This study investigates the multi-priority admission problem across Endocrinology (ED), Cardio...

Enhancing prediction of pathological complete response to neoadjuvant immunotherapy in non-small cell lung cancer by whole-lung radiomics

To evaluate the utility of whole-lung radiomics for predicting pathological complete response (pCR) to neoadjuvant immunotherapy in patients with non-small cell lung cancer (NSCLC), and further explore whether integrating whole-lung radiomics with tumor-specific radiomics could e...

PTTG1-driven self-amplifying loop with SP1 and ENO1 promotes IRF4-mediated myeloma progression and bone destruction

Abstract Multiple myeloma (MM) is a neoplastic disorder of plasma cells within the hematopoietic system and is characterized by osteolytic lesions. Despite significant advances, the molecular underpinnings of myeloma and its associated bone pathologies remain elusive, and there i...

Expression level of lncRNA MIR210HG in high-grade serous ovarian cancer tissues and its correlation with clinicopathological features and prognosis

Abstract Objective To investigate long non-coding RNA (lncRNA) MIR210HG expression in high-grade serous ovarian cancer (HGSOC) and its correlation with clinicopathological features, clinical outcomes, and prognosis. Methods Tissue samples were collected from 84 patients with HGSO...

Chemotherapy Reawakens Dormant Disseminated Pancreatic Cancer Cells in the Liver by Promoting Senescent Hepatocyte-Induced Neutrophil Extracellular Traps

Abstract Chemotherapy remains a cornerstone treatment for pancreatic ductal adenocarcinoma (PDAC), yet it paradoxically promotes metastatic recurrence. Elucidation of the underlying mechanisms mediating chemotherapy-induced metastasis could help identify improved combination trea...

Endoscopic submucosal resection with band ligation versus endoscopic submucosal excavation for small (≤ 10 mm) gastric muscularis propria-derived lesions: a real-world retrospective cohort study with long-term follow-up

The optimal management of small (≤ 10 mm) gastric subepithelial lesions (SELs) arising from the muscularis propria (MP) remains controversial. Endoscopic submucosal resection with band ligation (ESMR-L) is a simplified resection technique that may improve procedural efficiency co...

Integrative single-cell and spatial transcriptomic analysis reveals 4-HNE-related stromal remodeling in lung adenocarcinoma

Background 4-HNE is a lipid peroxidation product involved in oxidative stress, tumor microenvironment remodeling, and tumor progression. This study aimed to characterize the cellular distribution, prognostic relevance, and functional roles of 4-HNE-related molecular features in l...

Association between PD-1/PD-L1 Expression and Clinicopathological Parameters as well as Prognosis in Neuroendocrine Neoplasms of the Digestive System: A Systematic Review and Meta-Analysis

Abstract Neuroendocrine neoplasms (NENs) are a highly heterogeneous group of tumors originating from the neuroendocrine system, predominantly occurring in the gastrointestinal tract and lungs. This meta-analysis aimed to clarify the association of programmed death 1 (PD-1)/progra...

XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is an aggressive malignancy that responds poorly to immune checkpoint inhibitor (ICI) therapy, due to its immunosuppressive tumor microenvironment. Here, we analyse preclinical mouse tumor models and patient-derived SCLC samples and identify...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

SLC3A2 identified as a new therapeutic target for head and neck squamous cell carcinoma

The head and neck squamous cell carcinomas (HNSCC), which is the most common malignant tumor of head and neck region. Programmed cell death pathways, including the ferroptosis pathway and the disulphide cell apoptotic pathway, have received increasing amounts of attention as pote...