Tianjin Institute of Pharmaceutical Research (China)

The Effect of Taurine on the Alkalinity Stress Resistance of Eriocheir sinensis

High alkalinity, a major stress in saline–alkaline water, often leads to oxidative damage and apoptosis. Taurine has been shown to enhance the tolerance of aquatic animals to environmental stress, but whether it can reduce toxicity of alkalinity on Chinese mitten crab (Eriocheir...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Multi‐Stimuli Responsive Phosphate Hybrids With Visible‐Light‐Excited Dual‐Mode Afterglow Toward Multifunctional Applications

ABSTRACT Dual‐mode afterglow emission is a notable photoluminescent phenomenon in which materials exhibit prolonged luminescence via thermally activated delayed fluorescence (TADF) and phosphorescence. Developing such dual‐mode materials through a simple preparation process is in...

Ultrasound-Activated Janus Heterojunction-Mediated Enhanced Cascade Nanozyme for Inflammatory Bowel Disease Therapy

Abstract Inflammatory bowel disease (IBD) is exacerbated by the excessive accumulation of reactive oxygen species (ROS). To overcome the insufficient catalytic activity of conventional cerium-based nanozymes, we designed an ultrasound-activated Bi@BTC heterojunction nanozyme. The...