Tianjin Huanhu Hospital

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Development and validation of an interpretable prognostic model for in-hospital GCS-based neurological recovery after intracerebral hemorrhage in young and middle-aged adults: a multicenter retrospective cohort study

Prognostic tools for intracerebral hemorrhage (ICH) are largely derived from older or mixed-age cohorts and rarely incorporate lifestyle factors, limiting their relevance to young and middle-aged adults. We aimed to develop and externally evaluate an interpretable model for unfav...

Stratified meta-analysis of rodent diabetic neuropathy nerve transcriptomes identifies a down-regulated structural core

This record contains the derived data and analysis code for the study "Stratified meta-analysis of rodent diabetic neuropathy nerve transcriptomes identifies a down-regulated structural core" (manuscript submitted to Disease Models & Mechanisms, 2026). Twelve rodent (mouse and ra...

LDL-C–stratified residual lipoprotein(a) and inflammatory risk after acute myocardial infarction among patients with prior statin use

Abstract Background Patients can experience acute myocardial infarction (AMI) despite documented prior statin exposure, indicating persistent residual cardiovascular risk. The prognostic relevance of lipoprotein(a) [Lp(a)] and residual inflammation in this setting remains unclear...

Multiple-adverse health conditions, mental health, and health-related quality of life in stroke survivors: Latent profile analysis and mediation analysis

Objective This study aimed to identify subgroups of stroke survivors based on multiple-adverse health conditions and determine the potential mediation effects of mental health in their relationship with health-related quality of life. Design A cross-sectional study. Setting Three...

Intraplaque Hemorrhage in Chronic Anterior Circulation Arterial Occlusion: Associated Factors and Vessel‐Specific Patterns on High‐Resolution Magnetic Resonance Imaging

Background Chronic anterior circulation arterial occlusion, particularly involving the internal carotid artery or middle cerebral artery (MCA), carries a persistent risk of ischemic events. Intraplaque hemorrhage (IPH) is a marker of plaque instability, but its prevalence, vessel...