Tianjin Hospital

The Impact of a Multidimensional Intraoperative Pressure Injury Prevention Protocol on Postoperative Pressure Injuries Incidence in Elderly Patients Undergoing Internal Fixation for Hip Fracture

AIM: To retrospectively analyze the comparative effectiveness of a multidimensional intraoperative pressure injury prevention protocol versus routine nursing care in elderly patients undergoing internal fixation for hip fracture, by comparing the incidence of postoperative pressu...

Chromatin Modifications Orchestrate DNA Repair Pathway Choice: Epigenetics Strategies for Enhancing CRISPR –Cas9‐Mediated Knock‐In Efficiency

CRISPR-Cas9-mediated precise gene knock-in relies on homology-directed repair (HDR) at low frequencies in most mammalian cells, limiting precise gene editing in both research and therapeutic applications. Although multiple strategies have been developed to increase knock-in effic...

Pathological mechanisms of long non-coding RNA FOXD2-AS1 promoting osteosarcoma mediated by the COI-1/OCN/Runx-2 signaling pathway

Introduction Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite three decades of research efforts, no significant improvement in patient survival rates has been achieved, highlighting the urgent need for in-depth investigation i...

Multibody kinematic dimensional synthesis of a novel passive ankle exoskeleton with biomimetic kinematic response containment

Abstract To address uncertainty-induced kinematic response fluctuations in passive ankle exoskeletons, a bioinspired passive compliant ankle-exoskeleton structural concept is proposed. The design integrates four biomechanical subsystems: (I) a soleus muscle-inspired elastic-dampi...

Effect of electroacupuncture on postoperative delirium in older patients undergoing major surgery: a prospective, multicenter, randomized sham-controlled trial

Abstract Purpose Postoperative delirium (POD) is a common complication in older patients undergoing major surgery and is associated with prolonged hospitalization, delayed recovery, and increased mortality. This study evaluated whether perioperative electroacupuncture (EA) reduce...

Comparative Efficacy of Bone Defect Filler Strategies Following Lesion Debridement for Osteonecrosis of the Femoral Head: A Systematic Review and Network Meta‐Analysis

ABSTRACT Objective This study aimed to systematically review and compare the clinical and radiographic outcomes of different bone defect filler materials following lesion debridement for osteonecrosis of the femoral head (ONFH). Existing evidence on filler materials relies heavil...

Quality and reliability of cancer pain management information on short-video platforms in China: a cross-sectional content analysis

Short video platforms in China have evolved into primary digital health information channels. Their algorithm-driven ecosystems raise important questions about the quality and dissemination of specialized medical content, such as cancer pain management. This study aimed to assess...

Accuracy of ultrasound in diagnosing anterior talofibular ligament injury: a meta-analysis

The anterior talofibular ligament (ATFL) is the most frequently injured structure of the ankle joint. This meta-analysis evaluates the diagnostic accuracy of ultrasound for anterior talofibular ligament injury. We systematically searched for PubMed, Embase, Web of Science, Scopus...

Multiple-adverse health conditions, mental health, and health-related quality of life in stroke survivors: Latent profile analysis and mediation analysis

Objective This study aimed to identify subgroups of stroke survivors based on multiple-adverse health conditions and determine the potential mediation effects of mental health in their relationship with health-related quality of life. Design A cross-sectional study. Setting Three...

Association between the IL-35 rs583911 polymorphism and hepatocellular carcinoma risk in patients infected with chronic hepatitis B virus

Abstract Background The immunoregulatory cytokine interleukin (IL)-35 has been implicated in the pathogenesis of hepatocellular carcinoma (HCC). Here, we explored the association between single-nucleotide polymorphisms (SNPs) in the IL-35 gene and the occurrence of HCC in patient...

Evaluating the efficacy of a novel endometrial receptivity test in improving pregnancy outcomes for Chinese in vitro fertilization patients: a single-center retrospective study

Abstract Background Current evidence on whether endometrial receptivity tests improve pregnancy outcomes among in vitro fertilization (IVF) patients remains conflicting and limited. This study aimed to evaluate the efficacy of HerRecepta, a novel transcriptomic endometrial recept...

Age-Associated Patterns of Cardiovascular Risk and Disease Phenotypes Across Diverse Care Settings: The GLOB-cAGE Consortium

Reported prevalence of cardiovascular disease (CVD) risk factors and phenotypes varies widely. In multi-cohort analyses, such variation reflects population risk, care setting, and data capture. We harmonized baseline data from four analytic cohorts (N=54,188, aged ≥50 years) in f...

Investigating the association between angina and osteoporosis: a 20-year longitudinal cohort study of ELSA

Abstract Background Osteoporosis (OP) is recognized as a major global health threat. Although an association between angina and osteoporosis was established, the underlying mechanisms connecting the two conditions were not clearly elucidated. Therefore, this study aims to systema...

Deep learning-based analysis of paraspinal muscle changes in lumbar disc herniation

Lumbar disc herniation (LDH) is a predominant cause of low back pain, significantly affecting the quality of life of patients and closely linked to the condition of paraspinal muscles (PSM). However, existing two-dimensional (2D) measurement techniques that rely on muscle cross-s...

Construction of a nomogram prediction model for opportunistic sarcopenia in patients with malignant tumors.

BACKGROUND AND OBJECTIVES: The aim of this study was to establish a predictive model for opportunistic sarcopenia applicable to Chinese cancer patients, so as to quickly detect the occurrence of this condition and provide a basis for early clinical intervention. METHODS AND STUDY...