Tianjin First Center Hospital

Regional Adipose Distribution Reveals Differential Genetic Risk Patterns for Cardiometabolic Diseases

Background Cardiometabolic risk associated with obesity is increasingly recognized to be strongly influenced by the anatomical distribution and ectopic deposition of adipose tissue, yet the genetic mechanisms linking adipose depots to cardiometabolic diseases remain incompletely...

Pathological mechanisms of long non-coding RNA FOXD2-AS1 promoting osteosarcoma mediated by the COI-1/OCN/Runx-2 signaling pathway

Introduction Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite three decades of research efforts, no significant improvement in patient survival rates has been achieved, highlighting the urgent need for in-depth investigation i...

Dynamic kinetics of graft-derived cell-free DNA and personalized tacrolimus target ranges for acute rejection monitoring in pediatric liver transplantation

Introduction Acute rejection remains the most common complication during the early post-transplantation period for pediatric patients. Given the limitations of current diagnostic strategies, there is an urgent need to develop accurate and noninvasive biomarkers for allograft moni...

Prevalence and geographic variation of enteric pathogens among asymptomatic individuals in China: a nationwide, cross-sectional, multiplex molecular survey

The increasing use of multiplex molecular assays has improved the detection of enteric pathogens, but baseline carriage in asymptomatic populations remains poorly characterized, complicating the interpretation of positive test results. We aimed to investigate the prevalence and g...

Transformer‐Based Multitask Framework Integrating Habitat and Deep Learning for Predicting Early Disease Control and Survival in Immunotherapy‐Treated Hepatocellular Carcinoma

ABSTRACT Hepatocellular carcinoma (HCC) patients show heterogeneous responses to immune checkpoint inhibitors (ICIs). This study developed ECOS‐Net, a transformer‐based multitask network integrating CT‐derived habitat and 2.5‐dimensional (2.5D) deep learning features for simultan...

Estradiol Promotes Tumor Progression in ERα‐Low Endometrial Cancer via the GPER/SphK1 Pathway

ABSTRACT Endometrial cancer (EC) is the most common gynecological malignancy in postmenopausal women. Patients with low estrogen receptor alpha (ERα) expression frequently develop aggressive pathological subtypes and have poor prognosis. The role of estradiol (E2) in ERα‐low EC r...

Diagnostic accuracy and prognostic value of lncRNA H19 in gastric cancer: a systematic review and meta-analysis

Abstract Background LncRNA H19 is upregulated considerably in gastric cancer and participates in its apoptosis, proliferation, migration, invasion, and metastasis. The objective of this meta-analysis is to demonstrate its diagnostic and prognostic values for gastric cancer. Metho...

Systemic inflammatory factors combined with HR-VWI-based plaque vulnerability discriminate ischemic phenotypes and predict prognosis in patients with intracranial atherosclerosis

Abstract Background The relationship between systemic inflammation, plaque vulnerability, and stroke phenotypes in intracranial atherosclerotic stenosis (ICAS) is unclear. This study investigated inflammatory markers’ association with high-risk plaques and their value in differen...

Comparison of baseline characteristics between cognitively normal and mild cognitive impairment and association of white matter hyperintensity trajectories with diagnostic outcomes, cognition, and amyloid-β protein: A longitudinal study

Background White matter hyperintensity (WMH) is linked to mild cognitive impairment (MCI) and vascular dementia, but its longitudinal change as an independent risk factor remains unclear. Objective This study aims to compare baseline WMH across diagnostic outcomes, and evaluate h...

Endoscopic submucosal resection with band ligation versus endoscopic submucosal excavation for small (≤ 10 mm) gastric muscularis propria-derived lesions: a real-world retrospective cohort study with long-term follow-up

The optimal management of small (≤ 10 mm) gastric subepithelial lesions (SELs) arising from the muscularis propria (MP) remains controversial. Endoscopic submucosal resection with band ligation (ESMR-L) is a simplified resection technique that may improve procedural efficiency co...

Woven dECM yarn scaffolds enable volumetric muscle loss regeneration via immunomodulation

Volumetric muscle loss (VML) represents a significant unmet clinical need in current medical practice. Decellularized extracellular matrix (dECM) offers a promising clinical approach. However, its inherent architecture impedes adaptive topological guidance for rapid cellular infi...

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

To date, the treatment of acute myeloid leukaemia (AML) remains a major challenge in hematologic malignancies, particularly among elderly patients who are unfit for intensive chemotherapy. Venetoclax, a BCL-2 inhibitor, in combination with azacitidine, has significantly improved...

Association between PD-1/PD-L1 Expression and Clinicopathological Parameters as well as Prognosis in Neuroendocrine Neoplasms of the Digestive System: A Systematic Review and Meta-Analysis

Abstract Neuroendocrine neoplasms (NENs) are a highly heterogeneous group of tumors originating from the neuroendocrine system, predominantly occurring in the gastrointestinal tract and lungs. This meta-analysis aimed to clarify the association of programmed death 1 (PD-1)/progra...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Atomically Precise Pt 3 Cu 2 Clusters Restore Energy Metabolism via Targeted Succinate Degradation

ABSTRACT Succinate is a critical intermediate for the tricarboxylic acid cycle, whose abnormal accumulation can disrupt energy homeostasis and trigger systemic inflammatory injury across dominant metabolic organs. Targeting succinate thus represents a pivotal strategy to reestabl...

Chidamide plus venetoclax as effective and safe maintenance therapy in high-risk acute myeloid leukemia and myelodysplastic syndrome post-transplantation

Abstract Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), yet effective maintenance strategies are currently lacking. The combi...

Impact of Multidisciplinary Integrated Rehabilitation on ICU-Acquired Weakness in Critically Ill Patients: A Prospective Cohort Study on Clinical Efficacy, Functional Recovery, and Correlation Analysis

Background ICU-acquired weakness (ICU-AW) affects 25%–65% of critically ill patients, prolonging ventilation and hospitalization, impairing quality of life, and increasing mortality. Objective To assess MIR's effect on ICU-AW, functional recovery, and links to clinical, inflammat...

Deep learning-based analysis of paraspinal muscle changes in lumbar disc herniation

Lumbar disc herniation (LDH) is a predominant cause of low back pain, significantly affecting the quality of life of patients and closely linked to the condition of paraspinal muscles (PSM). However, existing two-dimensional (2D) measurement techniques that rely on muscle cross-s...