Tianjin First Center Hospital

Atomically Precise Pt 3 Cu 2 Clusters Restore Energy Metabolism via Targeted Succinate Degradation

ABSTRACT Succinate is a critical intermediate for the tricarboxylic acid cycle, whose abnormal accumulation can disrupt energy homeostasis and trigger systemic inflammatory injury across dominant metabolic organs. Targeting succinate thus represents a pivotal strategy to reestabl...

Chidamide plus venetoclax as effective and safe maintenance therapy in high-risk acute myeloid leukemia and myelodysplastic syndrome post-transplantation

Abstract Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the leading cause of treatment failure in high-risk acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), yet effective maintenance strategies are currently lacking. The combi...

Impact of Multidisciplinary Integrated Rehabilitation on ICU-Acquired Weakness in Critically Ill Patients: A Prospective Cohort Study on Clinical Efficacy, Functional Recovery, and Correlation Analysis

Background ICU-acquired weakness (ICU-AW) affects 25%–65% of critically ill patients, prolonging ventilation and hospitalization, impairing quality of life, and increasing mortality. Objective To assess MIR's effect on ICU-AW, functional recovery, and links to clinical, inflammat...

Deep learning-based analysis of paraspinal muscle changes in lumbar disc herniation

Lumbar disc herniation (LDH) is a predominant cause of low back pain, significantly affecting the quality of life of patients and closely linked to the condition of paraspinal muscles (PSM). However, existing two-dimensional (2D) measurement techniques that rely on muscle cross-s...