Tianjin Chest Hospital

CD34+ myofibroblasts promote neointima formation in vein grafts by activating ferroptosis-induced smooth muscle cell phenotype switch

Abstract Aim Vein graft (VG) failure due to adverse remodeling and aggressive neointimal hyperplasia is a major complication and key limiting factor for maintaining long-term VG patency. CD34+ cells have been implicated in multiple cardiovascular diseases, but their functional in...

Non-monotonic cardiovascular adaptation and stroke output-stroke output coupling reorganization in high-altitude adolescents: a cross-sectional study along altitude gradients

Abstract Cardiovascular adaptation to chronic high-altitude exposure during adolescence remains incompletely understood because developmental autonomic regulation may differ from adult acclimatization. We examined whether cardiovascular responses vary non-monotonically across alt...

Single-cell and bulk RNA sequencing demonstrate the critical function of the regulatory T cell-associated gene SIRPG in the prognosis and tumor microenvironment of esophageal squamous cell carcinoma

Immunosuppression by regulatory T cells (Tregs) significantly contributes to poor prognosis of esophageal squamous cell carcinoma (ESCC), although the specific regulatory genes and mechanisms involved are not well understood. We analyzed single-cell RNA sequencing and bulk transc...

Dynamic kinetics of graft-derived cell-free DNA and personalized tacrolimus target ranges for acute rejection monitoring in pediatric liver transplantation

Introduction Acute rejection remains the most common complication during the early post-transplantation period for pediatric patients. Given the limitations of current diagnostic strategies, there is an urgent need to develop accurate and noninvasive biomarkers for allograft moni...

Transcatheter aortic valve-in-valve implantation for residual prosthetic valve dysfunction and paravalvular leak after healed Enterococcus faecalis prosthetic valve endocarditis: a case report

Abstract Background Prosthetic valve endocarditis (PVE) is associated with substantial morbidity and mortality, particularly when complicated by severe prosthetic valve dysfunction and paravalvular leak. Although redo surgery remains the standard treatment, some patients may be u...

2026 Chinese expert consensus on perioperative management for left ventricular assist device implantation in adults

Abstract Purpose This consensus was developed to address the lack of standardized perioperative management protocols for left ventricular assist device (LVAD) implantation in China and to build on recently published national consensus documents addressing preoperative and postope...

Lactylation-related immune-metabolic dysregulation defines prognostic and therapeutic stratification in lung adenocarcinoma

Background Lactylation links lactate metabolism with inflammatory signaling and immune regulation in tumors. However, its cellular distribution and translational value in lung adenocarcinoma (LUAD) remain unclear. Methods Single-cell RNA-sequencing datasets GSE189357 and GSE17114...

Perioperative recovery and survival after lobectomy versus sublobar resection in adults aged ≥ 70 years with NSCLC ≤ 3 cm: complementary SEER and real-world cohort analyses

For older adults with non-small cell lung cancer (NSCLC), the choice of resection must balance durable cancer control against physiological reserve and postoperative recovery. We combined population-level long-term survival data with granular real-world perioperative data to exam...

Ambient cold exposure and myocardial infarction risk in Tianjin, China: a distributed lag non-linear analysis

Abstract Background Ambient temperature is an important environmental determinant of cardiovascular health. Although cold exposure has been associated with acute myocardial infarction (MI), evidence on delayed effects and subtype-specific differences remains limited in northern C...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...