Thrombosis and Atherosclerosis Research Institute

Identifying methodological guidance used for systematic reviews, clinical practice guidelines, and health technology assessment for rare diseases: a scoping review protocol.

OBJECTIVE: This scoping review will identify methodological guidance relevant to systematic reviews (SRs), clinical practice guidelines (CPGs), and health technology assessments (HTAs) for rare diseases, and examine methodological challenges associated with their development. INT...

Insights into the Hospital Experiences of Patients and Caregivers Affected by Sickle Cell Disease in Ontario

Abstract Objectives Sickle Cell Disease (SCD) is a group of inherited blood disorders affecting over 6,500 people in Canada with around 3500 residing in Ontario. Despite frequent interactions with healthcare providers (HCPs), individuals with SCD face barriers such as delays, sti...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...