Third Xiangya Hospital

β3‑adrenergic receptor agonist improves recovery after volumetric muscle loss and is associated with increased intramuscular brown/beige adipogenic activity in mice

Abstract Background Volumetric muscle loss (VML) often results in chronic muscle weakness, limb dysfunction, and even permanent disability. Current research primarily focuses on cell and extracellular matrix transplantation, but there is a lack of studies on the physiologically s...

Global 30-Year Trajectory and Socioeconomic Disparities of Type 2 Diabetes Mellitus in Older Adults (1990–2021)

Background: Type 2 diabetes mellitus (T2DM) is an escalating global health crisis among aging populations, warranting a comprehensive epidemiological assessment to support evidence-based policy development. Methods: Using data from the Global Burden of Disease Study 2021, we exam...

Remote behavioural activation therapy for depressive symptoms among older adults in resource-limited settings: a protocol for a systematic review and meta-analysis

Depressive symptoms represent a severe mental health burden among older adults, particularly in resource-limited settings with scarce mental healthcare resources. Although behavioural activation is an established evidence-based intervention, the efficacy of remote behavioural act...

Non-prescription supportive care interventions for anticancer therapy-induced oral mucositis: protocol for a systematic review and meta-analysis

Abstract Background Oral mucositis (OM) is a common and debilitating complication of anticancer therapies, frequently resulting in pain, nutritional impairment, and potential treatment interruption. While several pharmacologic and device-based interventions have been evaluated, l...

Cross-population genome-wide meta-analysis identifies pancreatic cancer susceptibility loci and etiologic pathways

Abstract Background Pancreatic cancer is a fatal malignancy influenced by genetic, metabolic, and lifestyle factors. We aimed to identify susceptibility loci and clarify associated genes, biological pathways, and potential etiologic factors. Methods We performed a cross-populatio...

Computationally guided hapten design enables a colloidal gold immunochromatographic assay for rapid citalopram detection in water and dietary supplements

Citalopram, a widely prescribed selective serotonin reuptake inhibitor (SSRI), has emerged as an environmental and food contaminant owing to its extensive consumption and incomplete removal during wastewater treatment, posing potential risks to aquatic ecosystems and human health...

Dysfunction of CD58 in tumor immune evasion: from mechanistic regulation to therapeutic resistance

Abstract CD58, the primary ligand of the co-stimulatory receptor CD2, plays a crucial role in the formation of the immunological synapse (IS) and the initiation of antitumor immunity involving T cells and natural killer (NK) cells. Aberrant CD58 expression, resulting from genomic...

METTL3-mediated m6A modification of RBM39 promotes cancer stemness and tumor progression in head and neck squamous cell carcinoma

Abstract Background RBM39 plays an important regulatory role in multiple cancers. However, its systematic function across pan-cancer and its specific mechanism in head and neck squamous cell carcinoma (HNSC) remain unclear. Materials and methods In this study, we performed pan-ca...

Aplasia of the left common carotid artery with internal and external carotid arteries lacking separate origins and concomitant carotid–anterior cerebral artery anastomosis: a rare case report and literature review

Aplasia of the common carotid artery (ACCA) is a rare vascular anomaly. Patients are typically asymptomatic unless accompanied by other vascular abnormalities. This condition is usually associated with independent origins of the internal and external carotid arteries, whereas cas...

Integrated multi-omics decodes the AKI-to-CKD transition: from ensemble discovery to structure-guided translational targeting

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) constitutes a major global health burden. Identifying causal drivers remains challenging due to proteomic complexity and confounding biases. We aimed to construct a discovery framework to identify actio...

Periostin attenuates senescence of human placental mesenchymal stem cells and enhances diabetic wound healing in rats

Refractory diabetic wounds are still big trouble for patients with diabetes, causing great mental and economic burdens. The application of mesenchymal stem cells (MSCs) represents a promising therapeutic strategy, but replicative senescence during ex vivo expansion limits MSC sel...

Clinical characteristics and management of iatrogenic urological injuries in gynecological surgery: a retrospective analysis of 75 cases

To evaluate the incidence, clinical characteristics, primary management strategies, and long-term outcomes of urinary tract injuries after major gynecological surgeries. A retrospective analysis was conducted on a cohort of 34,568 major gynecological surgeries performed at our in...

Topologically distinct intratumoral heterogeneity scores for predicting high-risk pathological grades in invasive lung adenocarcinoma: A multicenter study across four institutions

High-risk subtypes of invasive lung adenocarcinoma (IAC), particularly micropapillary- or solid-predominant patterns, are closely associated with poor prognosis. This multicenter retrospective study developed and validated a predictive model for the preoperative identification of...

Engineered Hierarchical Porosity in Three-Dimensional-Printed Hydrogel Scaffolds Enhances Mesenchymal Stem Cell Therapy for Chronic Diabetic Wounds

Abstract Unhealing chronic diabetic wounds is a major clinical challenge, as it is rooted in the complex pathological microenvironment, including neuropathy, angiopathy, and chronic inflammation. Traditional treatment methods cannot fundamentally solve these problems. Inspired by...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone

ABSTRACT Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long‐acting PEGylated recombinant human growth hormone (PEG‐rhGH) formulations have been developed to reduce injection frequency and improve adherenc...

Oncogenic USP3 promotes hepatocellular carcinoma progression via K11/K48-specific deubiquitination and stabilization of YAP

Hepatocellular carcinoma (HCC) has a poor prognosis, necessitating therapeutic targets, while the role of ubiquitin-specific protease 3 (USP3) in HCC remains unclear. This study aimed to elucidate the function of the deubiquitinating enzyme USP3 in HCC. USP3 was found to be highl...

Using physiologically based pharmacokinetic modelling to optimize repaglinide and irbesartan dosing in Chinese population with SLCO1B1 polymorphism

Aim The first aim of this study was to develop physiologically based pharmacokinetic (PBPK) models for irbesartan (IRB) and repaglinide (REP) and then apply the REP/IRB PBPK model to describe the drug–drug interaction (DDI) of REP and IRB in the population with SLCO1B1 c.521 T &g...

TNF-α-responsive YAP1 promotes CCL20 expression in colorectal inflammation and cancer

Colitis-associated colorectal cancer (CAC) exemplifies how chronic intestinal inflammation can be converted into sustained epithelial programs and a permissive tumor microenvironment, yet the molecular linkage between inflammatory cytokine cues and chemokine outputs remains incom...