Third People's Hospital of Chengdu

Feasibility and perceptions among hemophilia patients and doctors towards ultrasound for the assessment of subclinical abnormalities in hemophilic joints

This study explores the feasibility and perceptions of using ultrasound (US) for identifying subclinical abnormalities in hemophilic joints from the perspectives of both patients and medical practitioners. This was a single-center pilot follow-up study that included multidiscipli...

BMI-adjusted handgrip strength as a functional index to assess fall risk among older adults

This study was devised to explore how body mass index-adjusted handgrip strength (HGS/BMI) is related to subsequent fall risk among older Chinese adults, while also examining whether HGS/BMI demonstrates more consistent associations and more stable sex-specific associations than...

Residual risk in the >90% adequate bowel preparation rate cohort: a real-world large-scale study

Abstract Background In large real-world cohorts with >90% bowel preparation adequacy, residual risk factors for inadequate cleansing remain underexplored. Methods This retrospective study included 15,193 consecutive eligible patients undergoing colonoscopy at a tertiary academic...

Trajectories of memory function before and after cardiovascular disease among hypertensive patients

The trajectories of cognitive function before and after cardiovascular disease (CVD) have been widely explored in the general population, but less is known in hypertensive patients who are regarded as the most vulnerable patients for both CVD and dementia. The cohort study was co...

Quantitative pericardial calcification score as an imaging marker for atrial fibrillation in constrictive pericarditis

Constrictive pericarditis (CP) is frequently complicated by atrial fibrillation (AF), which worsens prognosis. Prior studies only qualitatively described pericardial calcification in relation to AF, lacking quantitative thresholds. This study aimed to quantify pericardial calcifi...

Artificial intelligence across the emergency–disaster continuum: a scoping review and implications for nursing practice

Abstract Background Emergency care and disaster response are both characterised by surges in demand, time pressure and constrained resources. In this review, an emergency-disaster continuum was developed as an analytical lens for examining AI applications across routine emergency...

Pathogen-oriented mNGS is not equivalent to microbiome profiling: interpreting BALF mNGS diversity in ARDS

Gao et al. provide valuable data-linking bronchoalveolar lavage fluid metagenomic next-generation sequencing with inflammatory subphenotypes of acute respiratory distress syndrome. We highlight three issues relevant to interpretation: an apparent inconsistency concerning exclusio...

Head-to-head comparison of routinely ordered inflammatory markers, interleukin-6 and lactate for 28-day mortality in high-acuity ICU sepsis: a predominantly vasopressor-treated cohort

In intensive-care-unit (ICU) sepsis, C-reactive protein (CRP), procalcitonin (PCT), the white-cell count (WBC) and neutrophil-to-lymphocyte ratio (NLR) are commonly ordered and often interpreted prognostically. We compared their discrimination of 28-day mortality with interleukin...

Development and validation of an exosomal microRNA prognostic signature for BCLC stage A/B hepatocellular carcinoma

Hepatocellular carcinoma (HCC) exhibits remarkable prognostic heterogeneity within identical Barcelona Clinic Liver Cancer (BCLC) stages, thus requiring more precise molecular biomarkers. Exosomal microRNAs (miRNAs) are stable, non-invasive biomarkers that faithfully reflect the...

Efficacy and safety of five femtosecond laser platforms in cataract surgery: a network meta-analysis informing platform-specific clinical decision-making

Abstract Background To compare the efficacy and safety of five femtosecond laser platforms (FLPs) in femtosecond laser-assisted cataract surgery (FLACS) and guide clinical selection. Methods Systematic searches (PubMed, Cochrane Library, Web of Science, Embase, ClinicalTrials.gov...

Integrative genomic dissection of cardio-kidney-metabolic syndrome reveals novel loci, causal genes, and tissue-specific pathways in European populations

Cardiovascular-kidney-metabolic (CKM) syndrome has placed a substantial burden on society both socially and economically. But currently, little is known about the genetic structure of CKM syndrome. A multivariate genome-wide association study (GWAS) of CKM syndrome (mvCKM) in Eur...

3D-printed biochemical–biomechanical gradient scaffolds from high internal phase Pickering emulsion with dual gelatin-modulated gelling kinetics for enhanced osteochondral regeneration

Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

Beyond cholesterol: targeting ceramide signaling in cardiorenal metabolic crosstalk

Cardiovascular-Kidney-Metabolic (CKM) syndrome is associated with increased risks of cardiovascular mortality and target organ failure. Despite optimal lipid-lowering therapies, patients remain at substantial residual risk for adverse cardio-renal outcomes. Conventional cholester...

Unsupervised learning based on CT imaging in identifying subtypes of acute ischemic stroke severity

To explore unsupervised learning based on CT imaging for identifying severity subtypes of acute ischemic stroke (AIS) in the middle cerebral artery territory. One hundred seventy-three AIS patients were retrospectively enrolled. K-means clustering was performed on clinical and CT...

Mechanisms of ferroptosis in Echinococcus granulosus cyst fluid-induced hepatic injury and the protective role of Nrf2 activation

Cystic echinococcosis (CE) is a globally distributed parasitic zoonosis caused by infection with Echinococcus granulosus. This study investigated the ferroptosis mechanism in hepatocyte injury induced by Echinococcus granulosus cyst fluid (EgCF) and its relationship with the nucl...

Research on the dynamic evolution of competitive and water-film-mediated wear mechanisms of the carbon strips in the pantograph-catenary system at low temperature

Abstract To investigate the evolution of wear mechanisms in carbon strips at low temperature, this study conducted comparative friction tests on copper-impregnated carbon strips at room temperature (25 °C) and low temperature (-20 °C). To replicate operating conditions, the exper...

Engineering design of cobalt-based biomaterials for advanced cancer theranostics: Multimodal synergy, scalable fabrication, and clinical translation

Despite established modalities such as chemotherapy and radiotherapy, cancer treatment remains hindered by off-target toxicity, drug resistance, and adverse effects. Cobalt-Based Biomaterials (Co-BMs) have emerged as versatile nanoplatforms for tumor theranostics, leveraging reve...