Third People's Hospital of Chengdu

3D-printed biochemical–biomechanical gradient scaffolds from high internal phase Pickering emulsion with dual gelatin-modulated gelling kinetics for enhanced osteochondral regeneration

Three-dimensional (3D) printing enables the precise design of biomaterials at predefined spatial locations, representing a promising strategy for constructing highly organized osteochondral tissue with multiple morphogen gradients. However, most current 3D printing strategies lim...

Sintilimab plus Bevacizumab biosimilar IBI305 and chemotherapy as a first-line treatment in advanced gastric or gastroesophageal junction adenocarcinoma (SBAGA): a single-arm, phase Ib/II study

Adding anti-PD-1 or anti-VEGF therapy to chemotherapy improves survival in patients with advanced gastric cancer, yet outcomes remain poor. This Phase Ib/II trial aimed to evaluate the efficacy and safety of combining sintilimab, the bevacizumab biosimilar IBI305, and CapeOX chem...

Beyond cholesterol: targeting ceramide signaling in cardiorenal metabolic crosstalk

Cardiovascular-Kidney-Metabolic (CKM) syndrome is associated with increased risks of cardiovascular mortality and target organ failure. Despite optimal lipid-lowering therapies, patients remain at substantial residual risk for adverse cardio-renal outcomes. Conventional cholester...

Unsupervised learning based on CT imaging in identifying subtypes of acute ischemic stroke severity

To explore unsupervised learning based on CT imaging for identifying severity subtypes of acute ischemic stroke (AIS) in the middle cerebral artery territory. One hundred seventy-three AIS patients were retrospectively enrolled. K-means clustering was performed on clinical and CT...

Mechanisms of ferroptosis in Echinococcus granulosus cyst fluid-induced hepatic injury and the protective role of Nrf2 activation

Cystic echinococcosis (CE) is a globally distributed parasitic zoonosis caused by infection with Echinococcus granulosus. This study investigated the ferroptosis mechanism in hepatocyte injury induced by Echinococcus granulosus cyst fluid (EgCF) and its relationship with the nucl...

Research on the dynamic evolution of competitive and water-film-mediated wear mechanisms of the carbon strips in the pantograph-catenary system at low temperature

Abstract To investigate the evolution of wear mechanisms in carbon strips at low temperature, this study conducted comparative friction tests on copper-impregnated carbon strips at room temperature (25 °C) and low temperature (-20 °C). To replicate operating conditions, the exper...

Engineering design of cobalt-based biomaterials for advanced cancer theranostics: Multimodal synergy, scalable fabrication, and clinical translation

Despite established modalities such as chemotherapy and radiotherapy, cancer treatment remains hindered by off-target toxicity, drug resistance, and adverse effects. Cobalt-Based Biomaterials (Co-BMs) have emerged as versatile nanoplatforms for tumor theranostics, leveraging reve...