Third People 's Hospital of Chongqing

The dynamic connectome in Alzheimer's disease: From static snapshots to a symphony in time—A hypothesis

The static functional connectivity (sFC) model has established Alzheimer's disease (AD) as a large-scale brain network disorder, yet it rests on a questionable assumption of temporal stationarity. This assumption obscures the brain's intrinsic dynamics, which are essential for fl...

Validation of Newcastle ENDOPREM for assessing patient experience with colonoscopy: a multicenter prospective study

Patient experience is a key quality indicator for colonoscopy, yet standardized assessment tools are lacking in China. The Newcastle ENDOPREM scale has shown promise internationally but requires validation in China. To translate, adapt, and preliminarily evaluate the psychometric...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

BifunctionalIonophores for Cuproptosis Activation:Dual Targeting of Copper and Fe–S Protein Homeostasis

Abstract Cellular resilience to therapy often arises from adaptive mechanisms that safeguard iron–sulfur (Fe–S) proteins. Here, we present a rational strategy to overcome such resilience by integrating two synergistic vulnerabilities, copper toxicity and Fe–S cluster homeostasis,...