Third People 's Hospital of Chongqing

BifunctionalIonophores for Cuproptosis Activation:Dual Targeting of Copper and Fe–S Protein Homeostasis

Abstract Cellular resilience to therapy often arises from adaptive mechanisms that safeguard iron–sulfur (Fe–S) proteins. Here, we present a rational strategy to overcome such resilience by integrating two synergistic vulnerabilities, copper toxicity and Fe–S cluster homeostasis,...