Third Hospital of Hebei Medical University

Development and validation of a model to predict full thickness rotator cuff tear

Full-thickness rotator cuff tear (FTRCT) often requires surgical treatment. Magnetic resonance imaging (MRI) is the diagnostic gold standard; however, it is costly and resource-intensive. We aimed to develop and validate a clinical prediction model for FTRCT in patients with RCI,...

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

ABSTRACT Intervertebral disc degeneration (IVDD) is a major cause of low back pain and is closely associated with metabolic imbalance within the disc microenvironment, yet the underlying mechanisms remain poorly understood. Here, we identify ammonia accumulation as a metabolicall...

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...

Clinical efficacy of proximal femoral nail antirotation (PFNA) combined with denosumab in the treatment of osteoporotic intertrochanteric fractures

To investigate the clinical impact of PFNA internal fixation combined with denosumab on fracture healing, bone mineral density (BMD), hip joint functional recovery, and refracture incidence in patients with osteoporotic intertrochanteric fractures. A total of 99 elderly patients...

Biomechanical advantages of the proximal femoral bionic nail with triangular support structure in the treatment of intertrochanteric fractures: a coronal fracture heatmap modeling and finite element comparison of three implant designs

Coronal fracture fragments (CFs) are highly prevalent in intertrochanteric fractures and represent a significant risk factor for internal fixation failure. This study combined anatomical and engineering approaches to construct the first coronal fracture heatmap model and evaluate...

Surface-Engineered Phytochemical Nanomedicines for Postmenopausal Osteoporosis: Skeletal Targeting, Imaging-Supported Evaluation, and Therapeutic Performance

Postmenopausal osteoporosis (PMOP) is a metabolic bone disease driven by estrogen deficiency and a major contributor to fragility fractures, yet long-term use of current antiresorptive and anabolic agents remains constrained by tolerability and adherence. Plant-derived bioactive...

Characterizations of the multi-kingdom gut microbiota in elderly individuals with end-stage renal disease

End-stage renal disease (ESRD) is common in older adults and has been linked to gut dysbiosis, yet multi-kingdom alterations and cross-kingdom interactions in elderly patients remain incompletely defined. We characterized the gut bacteriome, mycobiome, and virome in elderly indiv...

Arthroscopic Fixation of Posterior Cruciate Ligament Tibial Avulsion Fractures With Single‐Suture and Dual EndoButtons via the Lateral Aspect of the Anterior Cruciate Ligament

Abstract Arthroscopic techniques have gradually replaced open surgery as a routine method for treating posterior cruciate ligament tibial avulsion fractures. However, traditional arthroscopic surgery is associated with problems such as limited visualization, unstable fixation, an...

Global, regional, and national burden of low-back pain attributable to smoking from 1990 to 2021: An age-periodcohort and joinpoint analysis of the Global Burden of Disease Study 2021

INTRODUCTION: Low-back pain (LBP) is the leading cause of disability worldwide. Although smoking is a well-established, modifiable risk factor that accelerates intervertebral disc degeneration, comprehensive spatiotemporal analyses of its attributable burden remain scarce. This s...

Association between the preoperative geriatric nutritional risk index and loss of walking independence 180 days after hip fracture surgery: A retrospective cohort study

Abstract Background Malnutrition may impair recovery after hip fracture, but the association between preoperative geriatric nutritional risk index (GNRI) and postoperative walking outcomes remains unclear. We examined the association between GNRI and loss of walking independence...

Physeal Sparing Posterior Cruciate Ligament Reconstruction in Paediatric Patients With Open Physes Using an Outside‐In Femoral Tunnel and a Low Tibial Tunnel

Abstract In recent years, with increasing participation of adolescents in sports activities, the incidence of posterior cruciate ligament (PCL) injuries in paediatric patients has been increasingly reported. Conventional PCL reconstruction techniques typically require drilling fe...

Study on the pathogenic mechanisms and clinical treatment of advanced glycation end products (AGEs) in diabetic complications

The accumulation of Advanced Glycation End Products (AGEs), resulting from the Maillard Reaction formed via exogenous intake from food and a hyperglycemic internal environment in the body, can cause or exacerbate various complications of Diabetes Mellitus. This article discusses...

Thrombus molecular markers and thromboelastogram as early predictors of venous thromboembolism after total knee arthroplasty in perioperative elderly patients

Elderly patients undergoing total knee arthroplasty have a higher incidence of venous thromboembolism (VTE) owing to age, surgical trauma, and other factors. Numerous studies have employed the Caprini scale and d -dimer levels to evaluate perioperative coagulation function and pr...

Automatic measurement of knee parameters in three-dimensional computed tomography models: a deep learning-based approach

This study evaluates a deep learning algorithm for automated measurement of knee parameters from three-dimensional (3D) computed tomography (CT) reconstructions. We analyzed 323 CT scans from patients with normal knee morphology (mean age 39.10 ± 11.34 years; 200 male), randomly...

Association of a structured perioperative nursing intervention pathway with recovery and psychological outcomes in patients undergoing lumbar spine surgery: a non-concurrent controlled study

Degenerative lumbar spinal stenosis (DLSS) is a common condition associated with pain, functional limitation, and psychological distress. Although lumbar fusion surgery can relieve symptoms, postoperative recovery may be influenced by perioperative nursing care. This study aimed...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...