Third Hospital of Changsha

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Time to benefit of perioperative immunotherapy among patients with resectable non-small-cell lung cancer

Abstract Background The optimal duration of perioperative immunotherapy for resectable non–small-cell lung cancer (NSCLC) remains undefined, and conventional efficacy measures provide limited insight into the temporal pattern of benefit emergence, for which time-to-benefit (TTB)...

Surgical approaches for screw fixation of calcaneal fractures: a systematic review

To systematically review and summarize the evidence related to different screw configurations in the internal fixation treatment of calcaneal fractures. This systematic review (PROSPERO registration CRD420261389986) employed a comprehensive literature search of PubMed/MEDLINE, Em...

Imipenem and relebactam pharmacokinetics in peritoneal fluid: microdialysis reveals infection-independent penetration

species. However, data on tissue-site pharmacokinetics are limited. We evaluated the peritoneal penetration of imipenem and relebactam in healthy and infected rats by using microdialysis. The animals received a single intravenous infusion of imipenem (45 mg/kg) and relebactam (22...