Third Affiliated Hospital of Zhengzhou University

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

ABSTRACT Microwave ablation (MWA) for large hepatocellular carcinoma (HCC) is frequently compromised by non‐uniform thermal distribution and immunosuppressive niche formation. To address these challenges, we engineered an injectable bimodal nanodepot (TCPD) via catalytic crosslin...

Associations of per- and polyfluoroalkyl substances exposure with gestational diabetes mellitus and effect modification by vitamin D status

Per- and polyfluoroalkyl substances (PFAS) could disrupt glucose homeostasis by inducing oxidative stress, inflammatory responses, and endocrine disruption. However, the association between PFAS and gestational diabetes mellitus (GDM) and its subtypes remains controversial. Addit...

Cardiovascular and kidney outcomes of semaglutide and the annual eGFR slope in adults with and without type 2 diabetes: data extraction sheet, analysis code and search records for a systematic review and meta-analysis of randomised controlled trials

Supporting materials for a systematic review and meta-analysis of randomised, placebo-controlled trials of semaglutide in adults with and without type 2 diabetes (PROSPERO CRD420261496524). Contents:(1) the standardised data extraction sheet used to record trial characteristics,...

Cardiovascular and kidney outcomes of semaglutide and the annual eGFR slope in adults with and without type 2 diabetes: data extraction sheet, analysis code and search records for a systematic review and meta-analysis of randomised controlled trials

Supporting materials for a systematic review and meta-analysis of randomised, placebo-controlled trials of semaglutide in adults with and without type 2 diabetes (PROSPERO CRD420261496524). Contents:(1) the standardised data extraction sheet used to record trial characteristics,...

A DNA methylation-based machine learning model for early and accurate diagnosis of cervical HSIL+ lesions

Abstract Current cervical cancer screening methods lack accuracy in early diagnosis and risk prediction. We developed a DNA methylation-based diagnostic model for cervical high-grade squamous intraepithelial lesions or more severe lesions (HSIL+). This study systematically collec...

Cardiovascular and kidney outcomes of semaglutide and the annual eGFR slope in adults with and without type 2 diabetes: data extraction sheet, analysis code and search records for a systematic review and meta-analysis of randomised controlled trials

Supporting materials for a systematic review and meta-analysis of randomised, placebo-controlled trials of semaglutide in adults with and without type 2 diabetes (PROSPERO CRD420261496524). Contents:(1) the standardised data extraction sheet used to record trial characteristics,...

Comparison of Continuous‐Time Random Walk and Fractional Order Calculus Diffusion Models for Preoperative Breast Lesion Characterization: Diagnosis, Biomarker Prediction and Molecular Subtyping

BACKGROUND: Accurate preoperative characterization of breast lesions is important for individualized management. The conventional monoexponential (Mono) model has limited ability to capture the complex microstructure of lesions. Non-Gaussian diffusion models, including continuous...

Microglial PGRN downregulation contributes to phagocytosis-mediated retinal microvascular endothelial cell damage in early experimental diabetes

Diabetic retinopathy (DR), a major cause of vision loss, involves retinal microvascular dysfunction. While microglial phagocytosis of endothelial cells has been reported to contribute to diabetic retinal damage, the endogenous mechanisms driving microglial hyperphagocytosis in ea...

Novel Compound Heterozygous STK4 Variants Associated with Combined Immunodeficiency, Impaired Thymic Output, and Altered FOXO1-BACH2 Signaling

Serine/threonine kinase 4 (STK4) deficiency is a rare combined immunodeficiency (CID). This study aims to analyze the clinical and immunological characteristics of a child carrying novel compound heterozygous STK4 variants and to explore potential alterations in FOXO1-BACH2 signa...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

Combined administration of fructooligosaccharides and Clostridium butyricum attenuates bowel cleansing-induced dysbiosis and safeguards mucosal defense in a murine model

Bowel preparation with polyethylene glycol electrolyte solution (PEG-ELS) is indispensable for gastrointestinal endoscopy and related procedures. However, it disrupts gut microbial homeostasis and increases host vulnerability to ensuing infection. In a murine model, we optimized...