Third Affiliated Hospital of Sun Yat-sen University

Predictive Value of Preoperative Examinations for Early Prognosis After Functional Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps

ABSTRACT Background Functional endoscopic sinus surgery (FESS) remains a primary treatment modality for chronic rhinosinusitis with nasal polyps (CRSwNP) refractory to medical management. This study aimed to evaluate the predictive value of routine preoperative examinations for e...

QCFSNet: A Quaternion-Guided Inter-Channel and Frequency-Spatial Feature Interaction Strategy for Endoscopic Image Segmentation

In the field of medical consumer electronics, particularly in cervical cancer diagnostics, endoscopic imaging is often affected by uneven illumination and the high similarity in textures and features between lesion regions and surrounding tissues, which severely hinders accurate...

Genetic Investigation of Pregnancies With an Isolated Fetal Pelvic Kidney

ABSTRACT Objective To explore genetic investigative results in fetuses with isolated pelvic kidney. Methods This was a retrospective study of 212 fetuses with isolated pelvic kidney diagnosed on second trimester anatomy ultrasound. All cases underwent invasive prenatal diagnosis...

Chest wall tissue microsporidiosis associated with metagenomic next-generation sequencing detection of Encephalitozoon cuniculi: a case report

Encephalitozoon cuniculi is an obligate intracellular microsporidian that typically causes clinically apparent disease in immunocompromised hosts, whereas symptomatic infection in individuals without recognized immunodeficiency is uncommon. We report a 57-year-old man without kno...

Orthodontic, regenerative, and implant management of a mandibular anterior defect: 5‐year outcome

Abstract Background Severe alveolar ridge defects in the mandibular anterior region, often associated with congenital tooth absence and subsequent loss of retained primary teeth, present significant challenges for implant rehabilitation. Limited space, horizontal ridge deficiency...

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

Perirenal fat thickness was associated with reduced estimated glomerular filtration rate in the hospital-based population: a mediation analysis

It is unclear how perirenal fat thickness (PrFT) and impaired renal function are related, particularly in patients with metabolic risk factors. A hospital-based cohort of individuals was examined to determine whether perirenal fat thickness, as measured by magnetic resonance imag...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...

Kirkendall Effect-Driven Construction of Hollow Rare-Earth Silicate Nanospheres for Drug Loading

Abstract Monodisperse oxide nanoparticles have attracted attention for biomedical applications. However, conventional synthetic methods often provide limited control over particle size, morphology, and polydispersity. Herein, we report a bottom-up strategy for synthesizing hollow...

Automated screening of autism via a pretrained vision-language model in naturalistic caregiver-child interactions

Early autism screening is essential for timely intervention but remains constrained by specialist dependence, costly protocols, and limited accessibility. We present Autism-CLIP, a vision-language model that automates screening from 3-min naturalistic caregiver-child interaction...

Mean apparent propagator MRI of distributed brain microstructure in anxiety-related heterogeneity among children with autism spectrum disorder: associations with thyroid hormones and trace elements

Anxiety-related symptoms contribute substantially to clinical variability in autism spectrum disorder (ASD), but the extent to which peripheral endocrine and trace-element measures map onto brain microstructure remains insufficiently defined. We investigated whether thyroid-relat...

A Novel Technique of Traction Pre‐Bladder Suturing in Single‐Position Robot‐Assisted Nephroureterectomy: Simplifying the Management of the Intramural Ureter

OBJECTIVE: To evaluate the feasibility and preliminary perioperative outcomes of a traction pre-bladder suturing technique for managing the intramural ureter during single-position robot-assisted laparoscopic nephroureterectomy (RALNU) in patients with early-stage upper tract uro...

Ethical tensions in AI-mediated clinical communication: a mixed-methods study of nursing students’ perspectives

The increasing use of artificial intelligence (AI), particularly large language models (LLMs), is reshaping clinical communication by influencing how patients access, interpret, and act upon clinical information. Recent conceptual work has suggested that AI-mediated communication...

A chemoresistance-associated proliferation gene signature identified by single-cell and machine learning analysis predicts prognosis in high-grade serous ovarian carcinoma

Background High-grade serous ovarian carcinoma (HGSOC) features extensive intratumoral heterogeneity, frequent chemoresistance and poor prognosis. Tumor proliferation kinetics reflected by tumor doubling time (TDT) are linked to therapeutic response, yet molecular drivers of chem...

A Wearable Multimodal Assistive Interface for Virtual Cursor Control in Stroke Survivors with Upper-Limb Impairment

Stroke survivors with upper-limb impairments often have difficulty using conventional computer interfaces, which limits their ability to perform daily computer-related activities independently. This study developed a wearable multimodal assistive interface that enables computer i...

Real‐World Glycemic Outcomes of Open‐Source Automated Insulin Delivery During 12 Months Among People With Type 1 Diabetes Across Age Groups

ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people wi...

Impact of Donor Age on Short‐Term Outcomes After Pediatric Split Liver Transplantation

BACKGROUND: Split liver transplantation (SLT) expands access to grafts for pediatric recipients, but the short-term implications of donor age at the extremes of the accepted range remain uncertain. METHODS: We retrospectively analyzed 144 pediatric SLT recipients treated from 201...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Clinicopathological analysis of distant metastasis in dermatofibrosarcoma protuberans: a report of 14 cases

BACKGROUND AND OBJECTIVES: Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma with a low metastatic rate; however, the prognosis worsens once distant metastasis occurs. We aimed to identify clinicopathological risk factors and molecular features associated with distant meta...