Third Affiliated Hospital of Sun Yat-sen University

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...

Blocking AGEs reduces airway epithelial viral susceptibility in diabetes-exacerbated COPD

Abstract Although diabetic complications are well-established in multiple organs, their impact on the respiratory system remains unclear. Clinical evidence indicates accelerated chronic obstructive pulmonary disease (COPD) progression in individuals with diabetes, yet the underly...

Clinicopathological analysis of distant metastasis in dermatofibrosarcoma protuberans: a report of 14 cases

BACKGROUND AND OBJECTIVES: Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma with a low metastatic rate; however, the prognosis worsens once distant metastasis occurs. We aimed to identify clinicopathological risk factors and molecular features associated with distant meta...

Integrated proteomic, transcriptomic, and epigenomic profiling identifies SRA1 as a novel therapeutic target for postpartum depression

Postpartum depression (PPD) is among the most common complications of childbirth, and identifying novel treatments is vital. We aimed to identify potential drug targets for PPD by integrating the plasma proteome, transcriptome and epigenome. We designed a comprehensive analysis p...

Quantitative analysis of dental prostheses materials on the magnitude of artefacts at different positions in cone-beam computed tomography: an ex vivo study

To evaluate the effect of crown materials for fixed prostheses on the image quality at different positions in Cone-Beam Computed Tomography (CBCT). A customized virtual maxillary model with three fixed abutments and six recesses was designed and fabricated using 3D printing. Six...

Cascading effect of early sensory differences on subsequent autistic traits in infants later diagnosed with autism: a prospective cohort study

Sensory differences constitute core diagnostic features of autism. The cascading effect model posits that early sensory differences may be prospectively associated with subsequent autistic traits, whereas empirical evidence in infancy remains scarce. This study aims to characteri...

Meningeal lymphatics orchestrate vertebral neutrophils via a Hex1Cer-NETs axis to promote autoimmune neuroinflammation

Abstract Meningeal enhancement is observed on cranial and spinal magnetic resonance image in a subset of patients with multiple sclerosis (MS) and is associated with a higher risk of future disease progression, however, the underlying mechanisms by which it promotes such progress...

A multi-class gastric biopsy artificial intelligence model developed from whole slide histopathological images

Pathological diagnosis of biopsies remains the gold standard for gastric diseases such as gastric carcinoma (GC), but it suffers from clinical misdiagnosis and high workload. Accurately distinguishing early-stage GC (EGC) from advanced-stage GC (AGC) and preoperatively predicting...

Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment

Stromal vascular fraction (SVF), an uncultured adipose-derived cell population, exerts regenerative effects primarily through paracrine mechanisms. While local intratesticular injection of SVF alleviates busulfan-induced testicular injury, the intravenous route remains unexplored...

Matrix Stiffness-Encoded Mechanical Memory Maintains Proliferative Dominance in Metastatic Tumors

Primary and metastatic lesions share similar biological properties despite existing in different microenvironments. A better understanding of the mechanisms underlying the maintenance of phenotypic homogeneity in heterogeneous microenvironments could help identify strategies for...

Machine learning prediction model of transition from acute kidney injury to acute kidney disease after liver transplantation: a retrospective study

The transition from acute kidney injury (AKI) to acute kidney disease (AKD) is a frequent sequela after liver transplantation (LT), associated with increased short-term mortality, prolonged hospitalization, and increased likelihood of progression to chronic kidney disease. Early...

Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation

Background Acetate is the metabolic precursor of acetyl-coenzyme A (CoA), fuelling histone acetylation. Objective We aimed to investigate whether the acetate-acetylation axis is hijacked in tumour endothelial cells (TECs) to govern hepatocellular carcinoma (HCC) progression. Desi...

The diagnostic value of cardiovascular magnetic resonance in hypertrophic cardiomyopathy

Limited studies compare the clinical applications and diagnostic values of cardiovascular magnetic resonance (CMR) versus echocardiography in individuals with hypertrophic cardiomyopathy (HCM). This study was performed to evaluate the diagnostic value of CMR in patients with HCM....