Third Affiliated Hospital of Southern Medical University

Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond

ABSTRACT The traditional drug discovery and development (DDD) pipeline has long been characterized by inefficiency and high costs. The rapid evolution of artificial intelligence (AI), especially AI‐based toolkits for protein structure and interaction prediction, exemplified by Al...

Regarding “Increased Elbow Valgus Torque During Pitching Is Not a Risk Factor for Medial Elbow Injuries in Young Baseball Pitchers: A Prospective Cohort Study”

We read with great interest the study by Saito et al.1 and commend the authors for addressing an important and clinically relevant question in youth throwing injury prevention. However, we believe that several important aspects were insufficiently addressed, and we respectfully o...

Eggshell-Templated Mn-Doped Hydroxyapatite Composite Scaffold: Coupling ROS Scavenging with Piezo1 Activation for Bone Regeneration

Abstract The treatment of critical-sized bone defects remains challenging due to immune microenvironment dysregulation characterized by excessive ROS, persistent inflammation, and apoptosis, which impede tissue regeneration. Conventional biomaterials often overlook the unique str...

CD147 is associated with NF-κB activation during the post-traumatic immune response in a murine trauma model

Abstract Extracellular matrix metalloproteinase inducer (CD147) has been proven to play a crucial role in a variety of inflammatory diseases but has not yet been investigated in trauma. The aim of the study was to investigate the role of CD147 in a murine model of trauma and hemo...

Barriers and facilitators of weight management in overweight and obese individuals: a qualitative study using the CFIR framework

Obesity is a major global health issue linked to chronic diseases. Maintaining a healthy body weight is an effective measure for preventing related disease but often faces implementation challenges. This qualitative study aims to identify facilitators and barriers to weight manag...

Wearable Electrochemical Sweat Sensors Beyond Snapshots With Long‐Term Stability

ABSTRACT Wearable sweat electrochemical sensors enable continuous and noninvasive monitoring of electrolytes, metabolites, and stress‐related biomarkers for personalized healthcare. However, the translation of these platforms from proof‐of‐concept prototypes to reliable clinical...

From peak performance to practical robustness in radiopharmaceutical design

Radiopharmaceutical research and development has been largely driven by the pursuit of high radiochemical yield (RCY) under optimized laboratory conditions. However, this emphasis on peak performance often overlooks a critical translational bottleneck: insufficient robustness und...

Transverse Tibial Transport Accelerated of Diabetic Wound Healing via Enhanced Wnt/β-catenin-Driven BMSCs Mobilization and Angiogenesis

BACKGROUND: The management of severe diabetic foot ulcers (DFUs) remains a major clinical challenge. Tibial cortex transverse transport (TTT) has emerged as an effective surgical intervention, but its underlying mechanism, particularly concerning stem cell mobilization and signal...

Sequential Integration of Microenvironment Regulation Utilizing Aggregation‐Induced Emission Luminogen‐Based Carbon Dots for Diabetic Wound Treatment

Effective management of diabetic wound healing remains challenging due to the complex wound microenvironment, characterized by persistent infections and inflammation, as well as obstacles in tissue repair, including impaired extracellular matrix (ECM) remodeling and re-epithelial...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice

Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-...