Third Affiliated Hospital of Guangzhou Medical University

Shear Wave Elastography of the Tibial Nerve and Lower Limb Nerve‐Muscle‐Tendon Complex in Diabetic Peripheral Neuropathy

Objectives To investigate the associations among diabetic peripheral neuropathy (DPN), diabetic tendinopathy, and diabetic myopathy and their respective influencing factors using shear wave elastography (SWE). Methods This study enrolled 65 diabetic patients (22 with DPN [PN‐DM g...

Comparison of sevoflurane and propofol on the novel oxygenation index and respiratory mechanics in gynecological laparoscopic surgery: a randomized controlled trial

The novel oxygenation index (NOI), which incorporates mean airway pressure (Pmean) as a key respiratory parameter, is increasingly being investigated for its enhanced ability to reflect patients’ pulmonary function compared to the traditional oxygenation index (OI). This study ai...

Reproductive history and age at natural menopause in US women: a cross-sectional analysis of National Health and Nutrition Examination Survey 1999 to March 2020

Objective: The associations of parity and gravidity with age at natural menopause (ANM) remain incompletely characterized. We examined parity‐ANM and gravidity‐ANM associations and explored non‐live-birth pregnancies descriptively in a nationally representative sample of US women...

Review Article: Cancer Surveillance for Early Detection of Liver Cancer in Patients with HBV Infection

BACKGROUND AND AIMS: Chronic hepatitis B virus (HBV) infection remains a major cause of hepatocellular carcinoma (HCC). Although antiviral therapy reduces cirrhosis and liver failure, HCC may still develop in patients with HBV, including in non-cirrhotic livers. This review aimed...

Illness Experiences and Supportive Care Needs of Patients With Early‐Onset Colorectal Cancer: A Qualitative Systematic Review

AIMS: To synthesise the holistic illness experiences and supportive care needs of patients with early-onset colorectal cancer across the entire disease trajectory. BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed in indivi...

Safety and efficacy of the automated liquid-phase embryo storage, Hatchferti: a pilot study

To date, no fully automated liquid-phase embryo tank has been implemented in assisted reproductive technology (ART) laboratory and its impact on the safety and efficacy of embryo storage remains unknown. To evaluate its performance, the Hatchferti group (HG) stored a total of 230...

Saquinavir inhibits pyroptosis by regulating NLRP3 degradation to alleviate acute lung injury

Background In critically ill patients, sepsis can precipitate acute lung injury (ALI), a syndrome with high incidence in intensive care settings. Pyroptosis plays an important role in ALI, highlighting its potential as a drug target. The NLRP3-mediated classical pyroptosis pathwa...

Genetic prioritization and multi-omic characterization of GNS-associated thromboinflammatory signatures in venous thromboembolism

Venous thromboembolism (VTE) remains a major cause of cardiovascular morbidity and mortality. Beyond dysregulated coagulation, accumulating evidence implicates immune and inflammatory pathways in thromboinflammatory susceptibility. However, the genetic determinants of VTE and the...

Evaluative performance of triglyceride-glucose-frailty index versus surrogate insulin resistance indices for advanced cardiovascular-kidney-metabolic syndrome, cardiometabolic multimorbidity, and mortality: the role of estimated glomerular filtration rate

Cardiovascular-kidney-metabolic (CKM) syndrome and cardiometabolic multimorbidity (CMM) carry substantial mortality, yet whether a composite index integrating insulin resistance and frailty shows stronger associations with advanced CKM syndrome, CMM, and mortality than convention...

Comparison of non-contrast, non-radiation percutaneous mechanical thrombectomy and catheter-directed thrombolysis in pregnancy-associated iliofemoral deep vein thrombosis: a propensity-matched retrospective cohort study

Iliofemoral deep vein thrombosis (DVT) during pregnancy poses considerable risks to both the mother and the fetus, making it essential to provide prompt, effective, and safe treatment options. Although catheter-directed thrombolysis (CDT) and percutaneous mechanical thrombectomy...

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

ABSTRACT Intrauterine injury triggers a self‐reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with h...

IS 26 -mediated circular bla KPC transposon in ST2483 Pseudomonas aeruginosa

ABSTRACT The global spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a critical clinical threat, with bla KPC as a key mobile carbapenem resistance gene. Here, we investigated a novel bla KPC-2 genetic element and its transmission in clinical ST2483 isolate PA10...

A multi-class gastric biopsy artificial intelligence model developed from whole slide histopathological images

Pathological diagnosis of biopsies remains the gold standard for gastric diseases such as gastric carcinoma (GC), but it suffers from clinical misdiagnosis and high workload. Accurately distinguishing early-stage GC (EGC) from advanced-stage GC (AGC) and preoperatively predicting...

Sex-dimorphic phenotypic divergence in metabolically driven thyroid nodules: the interplay of systemic inflammation and adiposity

Metabolic dysfunction has been increasingly implicated in thyroid nodule development; however, the sex-specific interplay between systemic glucolipotoxicity, adiposity, inflammation, and thyroid nodule risk remains poorly understood. This study aimed to evaluate the association b...