Theodor Bilharz Research Institute

Targeting mitochondrial dysfunction and apoptosis in 5-fluorouracil–induced cardiotoxicity using kaempferol-mediated selenium nanoparticles

Abstract 5-Flurouracil (5-FU) is still considered as one of the most popular antimetabolite chemotherapy drugs to treat a wide variety of solid tumors. Dose limiting toxicity on major organs, especially cardiovascular system limits the therapeutic use of 5-FU. The current paper a...

Detection of carbapenem resistance mechanisms in difficult-to-treat Pseudomonas aeruginosa clinical isolates from a tertiary care hospital in Egypt

Abstract Background The increasing incidence of carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a significant global health concern, particularly with the emergence of difficult-to-treat resistance (DTR), which seriously restricts therapeutic options. Therefore, we aimed...

Chemical investigation and anti-trichinellosis activity of some ficus species leaves: in silico supported in vitro study

Abstract Background Worldwide, trichinellosis is a zoonotic illness. Albendazole (ALB), the nowadays anti-trichinellosis drug, has side effects and insufficient effectiveness. Ficus species have ubiquitous health benefits. The current work aimed to assess the in vitro anti-trichi...

Phytochemical profiling, bioactivity and in silico studies of Capparis decidua Edgew (Forssk.) root bark extracts

Capparis decidua (Forssk.) Edgew., a perennial shrub prevalent in arid Africa and Asia, holds prominent status in Sudanese traditional medicine for inflammation, infections, and scorpion stings. Despite extensive ethnomedicinal use, particularly of root bark, comprehensive scient...