The Wistar Institute

Aberrant erythrocyte rigidity in JAK2 V617F myeloproliferative neoplasms underlies concurrent thrombosis and hemorrhage

Thrombotic events are the leading cause of death in myeloproliferative neoplasms (MPNs) driven by the JAK2 Val 617 →Phe (JAK2V617F) mutation. We investigated how JAK2V617F alters hemostasis and thrombosis in humans and in lineage-specific knockin mice to test whether red blood ce...

ERVmancer: a phylogeny-guided framework for decoding human endogenous retrovirus regulatory mechanisms in health and disease

Human endogenous retroviruses (HERVs), remnants of ancient infections, comprise approximately 8% of the human genome and influence development, immunity, and cancer. Their repetitive sequences complicate short-read analysis because reads often cannot be assigned to individual loc...