Institution
The Wallace H. Coulter Department of Biomedical Engineering
Recent research
- Health & MedicineOpen access
Reprogramming the tumor immune landscape through SPP1 targeting
Abstract Beyond its canonical roles in bone mineralization and extracellular matrix remodeling, secreted phosphoprotein 1 (SPP1) has emerged as a central regulator of the tumor microenvironment (TME), orchestrating immunosuppressive programs that drive immune evasion and tumor pr...
- Health & MedicineOpen access
Mild traumatic brain injuries (mTBI) can substantially impact quality of life, and repetitive mTBIs (rmTBIs) can amplify injury effects compared to a single injury. However, effective clinical treatments remain elusive, largely due to an incomplete understanding of the underlying...
- Engineering & TechnologyOpen access
Abstract Exoskeletons assist and augment movement, but their effects on proprioceptive feedback remain poorly understood due to challenges in making direct measures of sensory signals in humans. Here, we leveraged a benchtop animal model to begin to explore how mechanical context...
- Health & MedicineOpen access
Protein expression derived from scRNA-seq reveals lupus-induced acceleration of immune aging
Single-cell RNA sequencing (scRNA-seq) is widely established and excels at capturing transcriptional heterogeneity and signaling states. However, it lacks direct quantification of surface proteins, which are key determinants of immune cell identity and function. To enable protein...
- Health & Medicine
Abstract Global markers of myocardial function are limited in the information they provide, warranting the need for local markers that are sensitive and specific to myocardial physiology. Myocardial deformation, quantified by strain, is a robust marker of myocardial function that...
- BiologyOpen access
Mutation E300 recommended by protein language models gives ChrimsonR amplified photocurrent response
Abstract A central challenge in opsin engineering is identifying mutations that reliably improve desired functional properties, a task made difficult by the enormous mutation space and limited throughput of electrophysiological screening. Improving opsin properties such as photoc...
- Engineering & TechnologyOpen access
ABSTRACT Cell therapy combined with biomimetic polymer engineering offers a promising strategy for cardiovascular regeneration. Compartmentalizing single cells in hydrogels creates three‐dimensional (3D) micro‐niches that enhance bio‐responsiveness and the therapeutic efficacy of...
- Physics & SpaceOpen access
Multimodal 3D light-field and laser-speckle endoscopy
Minimally invasive surgery is a powerful technique that enables operations deep within the body while minimizing patient trauma and recovery time. Optical endoscopes are key to providing intraoperative vision but still face challenges due to the loss of essential senses, includin...
- Engineering & TechnologyOpen access
Abstract In nature, animals must rapidly regain coordinated locomotion after neuromuscular injury, but the earliest compensatory strategies remain unknown. We addressed this gap using a chronic, implantable kilohertz electrical stimulation (KES) system to reversibly block tibial...
- Health & Medicine
Background: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly associated with AMR. However, 30-60% of DSA + patients do not develop AMR, raising the possibility of local tissue adaptations to...
- Health & MedicineOpen access
AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing
ABSTRACT Diabetic foot ulcers are a major complication of diabetes characterized by persistent inflammation and impaired tissue repair, in part driven by aberrant activation of the cGAS‐STING innate immune pathway. Precision immunomodulation in the protease‐rich wound microenviro...
- Materials & EnergyOpen access
What is happening at the atomic level during the seed-mediated growth of copper on gold?
Bimetallic nanocrystals obtained via seed-mediated growth are typically analyzed using conventional electron microscopy and many interesting features at the atomic level are often missed. Here we report the seed-mediated growth of copper (Cu) on gold (Au) nanospheres for the synt...
- Health & MedicineOpen access
ABSTRACT Objective measurement of tremors is important for assessing the severity and preventing misdiagnosis of Parkinson's disease (PD). To address this demand, this study presents a multichannel, wireless, patch‐type tremor monitoring system that integrates a high‐repeatable f...