The University of Texas Health Science Center

Care of the Sexual or Gender Minority Community Living with Cystic Fibrosis: A Survey of United States and Canadian Multidisciplinary Health Care Providers

PURPOSE: Lesbian, gay, bisexual, transgender, queer, intersex, asexual, or another sexual or gender minority (LGBTQIA+) people face health inequities and commonly report health care avoidance. We examined how multidisciplinary subspecialist providers care for LGBTQIA+ people with...

Trends in Ophthalmic Hospital Transfers and Consultations Across US Academic Centers

Importance Academic medical centers increasingly serve as a safety net for urgent and complex ophthalmic conditions, yet trends in the demand for hospital-based ophthalmic services remain poorly characterized. Objective To characterize multi-institutional trends in ophthalmology...

Olorofim for Invasive Fungal Diseases in Patients with Limited or No Treatment Options: A Systematic Review

Olorofim, the first orotomide antifungal, is active against Aspergillus spp., Lomentospora prolificans, Scedosporium spp. and Coccidioides spp. We reviewed published clinical reports of olorofim in invasive fungal disease (IFD) with limited or no treatment options. PubMed/MEDLINE...

Clinical Efficacy and Safety of Fosmanogepix in Patients with Invasive and Refractory Fungal Infections: A Systematic Review

Background: Fosmanogepix is a first-in-class Gwt1 inhibitor with oral and intravenous formulations and broad in vitro activity, but its clinical evidence is scattered across small trials and case reports. We reviewed all identifiable human data from the searched sources on its ef...

Firearm owners’ support for policies regulating firearms left in vehicles

Abstract Purpose Firearms stolen from vehicles are a leading source of gun theft in the US. In response, there has been growth in the number of proposed and enacted policies at the state and local levels. Yet firearm owners’ attitudes toward policies regulating firearms left in v...

Mutations That Matter: Domain-Specific Mutational Hotspots in BRCA1 and Its Key Interactors Differ Between TCGA and BCGA Breast Cancer Cohort—An In Silico Analysis

Background: Patients with breast cancer (BC), and mostly triple-negative BC (TNBC), often exhibit poor prognosis due to variability in symptom manifestation and differential responses to treatment. TNBC among Indian women is the highest globally, contributing to increased mortali...

Simultaneous Versus Interval Sleeve Gastrectomy on Patients Requiring Left Ventricular Assist Devices for End-stage Heart Failure: A Retrospective, Single-Center Cohort Study

Durable Left ventricular assist devices (LVADs) are commonly employed as therapy in end-stage heart failure (ESHF). However, individuals with class II obesity (Body Mass Index (BMI) > 35 kg/m²) are often ineligible for heart transplant and have limited options. Laparoscopic sleev...

Making the Case: Demonstrating the Value of Pediatric Hospital Medicine to Hospital Leadership

Pediatric hospital medicine (PHM) has become a foundational component of inpatient pediatric care; however, its value is frequently evaluated through a narrow financial lens. This C-suite series piece examines how PHM's contribution to 'value' encompasses not only professional re...

Best practice recommendations for spoken and signed language interpreter-mediated clinical neuropsychological services

Objective: The increasing linguistic and cultural diversity of the United States population has intensified demand for equitable, patient-centered neuropsychological services. Yet, a persistent shortage of bilingual and multilingual neuropsychologists, across both spoken and sign...

Pediatric Hospital Medicine FTEs and Staffing Models

Appropriate physician staffing is essential to providing safe, high-quality care for hospitalized children. Many challenges exist in achieving optimal staffing, including financial constraints, coverage of off-hour shifts, recruitment shortages, and building models that promote s...

Advances in the management of pediatric morphea: a narrative review

Pediatric morphea, also known as localized scleroderma, is a rare autoimmune condition characterized by skin fibrosis and, in severe cases, deeper tissue involvement. This review highlights the epidemiology, clinical presentation, and diagnostic challenges associated with pediatr...

Characteristics of solid versus hematologic malignancies in people living with human immunodeficiency virus

People living with HIV (PLWH) face increased risks of both AIDS-defining and non-AIDS-defining malignancies. We characterized the age-standardized cancer burden, compared clinical characteristics and survival outcomes between hematologic and solid malignancies in PLWH, and perfor...

A multi-site benchmarking framework for scalable extraction of geriatric care constructs from electronic health records

Current Natural Language Processing (NLP) algorithms for detecting geriatric conditions are largely limited to domain-specific models that fail to capture the interdependent, multidimensional nature of comprehensive geriatric assessment. This study aimed to develop and evaluate a...

The Lived Experiences of Parent-Child Separation and Mental Health Needs Among Young Adults Experiencing Homelessness

Parent-child separation is common among young adult parents experiencing homelessness and has been described as traumatic, yet little is known about the parenting and separation experiences or related mental health needs among young adult parents experiencing homelessness. Using...

Gastrointestinal Bleeding Is Associated with Worse In-Hospital Outcomes in Patients with ST-Segment Elevation Myocardial Infarction: An Analysis of the National Inpatient Sample

Background/Objectives: Patients with ST-segment elevation myocardial infarction (STEMI) may develop gastrointestinal (GI) bleeding. We aimed to assess the impact of GI bleeding on in-hospital outcomes in patients with STEMI. Methods: This retrospective study was performed using t...

Examining the Interchangeability of Two Different Patient‐Reported Global Assessment Measures in an Observational Axial Spondyloarthritis Cohort

OBJECTIVE: The goal of this study was to determine if patient global assessment (PGA) scores reported by patients with axial spondyloarthritis (AxSpA) prior to the development of the ASDAS can be used as a substitute for the global item of the ASDAS formula. METHODS: Data from th...

Monoclonal antibodies inhibiting MMP-9 activity alleviate peripheral neuropathy in diabetic mice

Diabetic peripheral neuropathy (DPN) is a debilitating medical condition that affects millions of individuals, causing neuropathic pain and chronic wounds. Despite its substantial impact, there are currently no effective disease-modifying treatments available to prevent or revers...

Understanding CT Resolution Timeline in Acute Pyelonephritis: A Framework for Clinical Practice

Abstract Purpose: Acute pyelonephritis is diagnosed based on clinical and laboratory signs. Computed tomography (CT) is typically reserved for detecting complications or alternative diagnoses. Current guidelines do not recommend routine follow-up imaging when abnormalities are fo...

Sexual health and relationship training needs of the substance use workforce: findings from a cross-sectional study

People receiving treatment for substance use disorders and those in long-term recovery who have a history of sex and drug-linked behavior are at greater risk of substance use recurrence than those without a history of problematic sexualized drug use. Yet, recovery support service...

Cilostazol Treatment for Intracerebral Hemorrhage: Targeting Dural Lymphatics

BACKGROUND: The meningeal lymphatic system contributes to hematoma resolution and neurological recovery after intracerebral hemorrhage (ICH). We previously demonstrated that intraperitoneal cilostazol administration promotes dural lymphatic growth and enhances clearance of intrac...