The University of Kansas Health System

Association between time-to-antibiotics and clinical outcomes in neutropenic fever after hematopoietic stem cell transplant

BACKGROUND: Guidelines recommend empiric antibiotics within one hour for neutropenic fever, extrapolated primarily from sepsis literature. Whether modest variation in time-to-antibiotics (TTA) affects outcomes in antibiotic-naïve hematopoietic stem cell transplant (HSCT) recipien...

Nonoperative Management of Juvenile Osteochondritis Dissecans Lesions of the Medial Femoral Condyle: Comparing Cylinder Cast, Hinged Knee Brace Locked Into Extension, and Activity Modification

OBJECTIVE: Compare nonoperative treatment options in juvenile osteochondritis dissecans (OCD) lesions of the medial femoral condyle. DESIGN: Descriptive, retrospective cohort study. SETTING: Single academic pediatric tertiary referral center. PATIENTS OR PARTICIPANTS: Male/female...

Multi-Institutional Data for Faculty Well-Being Improvements Within and Across Medical Schools

Importance Burnout, engagement, and satisfaction vary in prevalence and correlate with organizational performance in US medical colleges. Large-scale improvements have been elusive. Objective To quantify rates of well-being and its organizational correlates so to help identify op...

Clinical Outcomes and Hospital Resource Utilization Among Patients with Sepsis and COVID-19 Infection: Insights from the United States National Inpatient Sample Analysis, 2020–2022

Background/Objectives: Clinical studies have shown that patients who had sepsis with COVID-19 infection had worse clinical outcomes; however, there is a paucity of data on the association between concurrent COVID-19 infection and outcomes among patients with sepsis. Hence, we con...

Urinary Tract Infection Diagnosis—A Companion to the American Academy of Pediatrics’ 2026 Clinical Practice Guideline on the Diagnosis and Management of Urinary Tract Infection: Technical Report

Accurate diagnosis is essential to appropriate care. Although urinary tract infection (UTI) is one of the most common bacterial infections in children, there is no gold standard for its diagnosis. During the American Academy of Pediatrics' revision of its Clinical Practice Guidel...

A Systematic Review and Meta-Analysis of the Prevention and Management of Pediatric Urinary Tract Infection and Suspected Urinary Tract Infection: Technical Report

BACKGROUND AND OBJECTIVE: Urinary tract infection (UTI) is a common bacterial infection during childhood. This article reports on a technical review investigating the management of UTI to inform the development of an updated clinical practice guideline (CPG) by the American Acade...

A Systematic Review and Meta-Analysis of the Role of Ultrasonography for the Diagnosis of Vesicoureteral Reflux in Pediatric Patients Following Urinary Tract Infections: Technical Report

BACKGROUND: Vesicoureteral reflux (VUR) may be present in as many as 40% of children without known underlying neurogenic bladder or anatomic abnormalities in whom a first urinary tract infection (UTI) is diagnosed. This article reports on a technical review investigating the diag...

Clinical Practice Guideline for the Diagnosis and Treatment of Urinary Tract Infection in Children From 8 Days to 5 Years of Age

Urinary tract infection (UTI) is one of the most common bacterial infections in infants and young children, with a prevalence of 7% in infants with fever. This clinical practice guideline (CPG) provides an update of the literature and clinical recommendations of the 2011 American...

Safety and Adverse Event Profile of Procedural Sedation for Pediatric Burn Wound Care: A Single-Center Retrospective Cohort Study

Abstract Procedural sedation is essential for pediatric burn care, yet standardized, evidence-based regimens are lacking. This study characterizes the safety profile and pharmacological predictors of adverse events (AEs) in intensivist-led pediatric burn sedations. We conducted a...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

A Reassessment of Prophylactic Antibiotics in Low‐Infection‐Risk Electrophysiology Procedures

ABSTRACT Certain electrophysiology (EP) procedures are associated with minimal tissue disruption and do not involve permanent transvenous leads. As a result, these interventions carry a lower risk of device‐ or procedure‐related infection. These procedures include placement of im...

Patient‐Specific Computational Fluid Dynamics Modeling of Airway Collapse in Infants With Robin Sequence

ABSTRACT Robin Sequence (RS) is a congenital condition in which patients experience dynamic, periodic obstruction or collapse of the upper airway due to an underdeveloped jaw and a posteriorly displaced tongue. Current clinical techniques for evaluating airway obstruction do not...