The Third People's Hospital of Dalian City

Cellular subpopulation remodeling and biphasic molecular dynamics in glioma recurrence: a multi-omics analysis and diagnostic markers screening using liquid biopsy samples

OBJECTIVE: Glioblastoma (GBM) is a highly aggressive brain tumor with a median survival of about 15 months and frequent recurrence. Liquid biopsy of cerebrospinal fluid (CSF) and plasma enables minimally invasive detection of tumor-associated molecular signals and may improve ear...

The clinicopathological and molecular characterization in ascites-derived paraffin-embedded cell blocks of ovarian cancer

Abstract This study evaluated immunohistochemical (IHC) markers and homologous recombination repair (HRR) gene mutations in 58 ovarian cancer patients using ascites-derived paraffin-embedded cell blocks. IHC analysis revealed high expression of Pax-8 (87.5–100%), WT-1 (87.8–90%),...

Analysis of the factors influencing the treatment zone area after overnight orthokeratology lens wearing

Abstract Purpose To validate the agreement between R language (R) and MATLAB for measuring orthokeratology (OK) lens treatment zone parameters, and identify the influencing factors of the treatment zone area (TZA). Methods A retrospective study included 239 children (7–16 years)...

Perioperative severe airway hemorrhage during veno-arterial extracorporeal membrane oxygenation for acute massive pulmonary embolism

Rationale: According to the 2019 ERS/ESC guidelines, high-risk pulmonary embolism is defined as a case that presents with hemodynamic instability, obstructive shock, or cardiac arrest, and this condition has an extremely high death rate. ECMO can provide temporary circulatory sup...

Interpretable AI-driven materiomics to decode microenvironmental cues for stem cell immunomodulation

Abstract Hydrogels that mimic the extracellular matrix create microenvironments containing diverse physicochemical cues that regulate stem cell fate, particularly their immunomodulatory and pro-regenerative functions. However, elucidating how microenvironmental cues regulate cell...