The Third Affiliated Hospital of Zhejiang Chinese Medical University

Gui Gan Shen Mai Yin attenuates cardiac hypertrophy and dysfunction in association with mitochondrial homeostasis and the PI3K/AKT1 signaling pathway

This study aimed to evaluate the effects of Gui Gan Shen Mai Yin (GGSMY) on cardiac hypertrophy and dysfunction and to explore associated mechanisms. The chemical profile of the GGSMY aqueous extract was characterized using UPLC-MS. Candidate active ingredients and potential targ...

Rhein-induced free fatty acid generation cooperates with silver ions for biofilm-infected diabetic wound healing

Diabetic foot infection (DFI) significantly increases the risks of hospitalization and amputation, with biofilm infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and carbapenem-resistant Escherichia coli (CREC) being key drivers of treatment failure. Here, w...

Electroacupuncture reverses task-dependent long-term memory deficits in rats with chronic neuropathic pain

Abstract Background Chronic pain is frequently accompanied by cognitive dysfunction, while according to the limited cognitive resource hypothesis, persistent pain may consume finite neural processing capacity, thereby impairing cognitive performance, particularly under high cogni...

Adjunctive transcranial direct current stimulation after ultrasound-guided injection is associated with improved post-stroke shoulder pain outcomes

Post-stroke shoulder pain can interfere with upper-limb rehabilitation and daily functioning. This single-center retrospective cohort study evaluated whether initiation of adjunctive transcranial direct current stimulation (tDCS) within 48 h after ultrasound-guided shoulder injec...

Effect of Sequential Electroacupuncture Combined With Augmented Reality Gait Training on Walking Function and Neuromuscular Control in Subacute Stroke

OBJECTIVE: To investigate the effects of sequential electroacupuncture (EA) combined with augmented reality (AR) gait training on walking function and neuromuscular control in patients with subacute stroke (onset 1-6 mo). DESIGN: A single-blind, randomized controlled trial alloca...

Involvement of phosphorylated caveolin-1 in the dorsal root ganglion in diabetic neuropathic pain and the interventional effect of electroacupuncture

OBJECTIVE: The aim of the study was to observe the changes in phosphorylated caveolin-1 (p-Cav-1) expression in the dorsal root ganglion (DRG) of rats with diabetic neuropathic pain (DNP) and to explore the interventional effect of electroacupuncture on Cav-1. METHODS: In experim...

Safety of TNF-α inhibitors, IL-17 inhibitors, and JAK inhibitors in the treatment of axial spondyloarthritis: a protocol for a multi-method study integrating FAERS data mining, dose–response network meta-analysis, and drug-target Mendelian randomization

Biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs), including tumor necrosis factor-α inhibitors (TNFi), interleukin-17 inhibitors (IL-17i), and Janus kinase inhibitors (JAKi), are standard treatments for axial spondyloarthritis (axSpA). However...

Innovative treatment strategies for impacted maxillary central incisor and case comparisons

Background: The present article compares innovative treatment strategies for impacted maxillary central incisors, emphasizing the critical importance of prioritizing root development over rapid crown alignment. Methods: Two case reports using distinct clinical approaches are pres...

Construction and validation of a prediction system for postherpetic neuralgia: based on meta-analysis

Postherpetic neuralgia (PHN) is a chronic and intractable pain disorder. Existing PHN prediction systems have limited clinical applicability. A systematic search of the literature was conducted in PubMed, Web of Science, Embase and the Cochrane Library between 1950 and 2025, fina...

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Postoperative pain impairs patients' quality of life. Mechanisms underlying postoperative pain remain incompletely understood. We investigated postoperative pain in a mouse model of skin plus deep tissue incision (INC). We found Cxcl5 was among the top upregulated genes in incisi...

Patient Characteristics and Engagement in CGM‐Supported Virtual Weight Management

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.