The Second Nanning People's Hospital

A MAM-targeted integrated atomic-precision MnSe janus nanozyme platform inhibits pyroptosis and ferroptosis for intervertebral disc degeneration therapy

Aberrant endoplasmic reticulum (ER)–mitochondria crosstalk at mitochondria-associated ER membranes (MAMs) drives oxidative stress, calcium dysregulation, pyroptosis, and ferroptosis in nucleus pulposus cells, accelerating intervertebral disc degeneration (IVDD). Nanozymes that mi...

Comprehensive pan-cancer analysis of DIMT1 reveals its prognostic significance and immune-associated characteristics with experimental validation in gastric cancer

Abstract Background Dimethyladenosine Transferase 1 (DIMT1) is an rRNA-modifying enzyme involved in ribosome biogenesis; however, its potential oncogenic relevance and immune-associated characteristics across human cancers remain incompletely understood. Here, we aimed to systema...

Monotropein mitigates atherosclerotic plaque vulnerability through circ_0140736/miR-495/SIRPα-mediated efferocytosis

Efferocytosis is a biological process in which phagocytic cells engulf and degrade senescent, damaged, or dead cells to prevent secondary necrosis and inflammation. This process is implicated in various diseases, including atherosclerosis (AS). Enhancing efferocytosis efficiency...

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

Balloon guide catheter outcomes by occlusion site in the randomized PROTECT-MT trial

Background Balloon guide catheters (BGCs) are used during endovascular thrombectomy, but whether their effect varies by occlusion site is uncertain. We evaluated effect modification by baseline occlusion site in the PROTECT-MT trial. Methods This exploratory secondary analysis of...

Environmental and system-level factors associated with emergency medical service utilization and immediate on-scene symptom response: a population-based study

Abstract Background Suspected cardiopulmonary emergencies represent a major component of EMS demand and are highly sensitive to environmental exposures. However, the combined impact of these dual macro-environmental and micro-operational stressors on prehospital treatment effecti...

Intratumoral and peritumoral CT radiomics-clinical feature fusion model for differentiating pulmonary tuberculosis and pulmonary cryptococcosis nodules

Abstract Objective To investigate the clinical value of a fusion model combining intratumoral and peritumoral CT radiomics features with clinical features for differentiating pulmonary tuberculosis (PTB) from pulmonary cryptococcosis (PC) nodules, and to develop a predictive tool...

Latent class analysis of sexual behavior and HIV testing profiles among sexually experienced college students in China: a cross-sectional online survey

Rising human immunodeficiency virus (HIV) infections among young people underscore the need to strengthen campus-based prevention. We used latent class analysis (LCA) to summarize sexual behavior and HIV-testing profiles among sexually experienced college students, examine associ...

Bioinformatics-based analysis of key genes associated with endoplasmic reticulum stress in myocardial infarction

Abstract Background Endoplasmic reticulum stress (ERS) is a critical pathological factor that drives myocardial infarction (MI) progression. This study aimed to screen and validate core ERS-related hub genes involved in acute myocardial infarction (AMI) pathogenesis by integratin...