The Research Council of Norway

Melatonin beyond chronobiology: integrating pharmacokinetics, dose-exposure forecasting, and clinical evidence

Abstract Melatonin is established as a regulator of circadian timing and sleep, while a wider range of receptor-dependent and receptor-independent biological effects has generated interest in additional therapeutic applications. This review critically examines whether those propo...

Combined ROC curves for MRCC-I, MPGES, 8-isoprostane, and cPLA2 increase their discriminative value as biomarkers of autism spectrum disorders

Emerging evidence implicates mitochondrial dysfunction, oxidative stress, and neuroinflammation as key interrelated mechanisms underlying ASD pathophysiology. These molecular disturbances contribute to neuronal dysfunction through a self-reinforcing cycle, wherein mitochondrial i...