The Netherlands Cancer Institute

Persistent Health Disparities Among Adult Cancer Survivors

ABSTRACT Cancer survivors face elevated risks of age‐ and treatment‐related health conditions, possibly due to accelerated biological aging from cancer therapy. The role of social determinants of health (SDOH) in these aging trajectories remains understudied. We conducted a retro...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Diagnostic value of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in staging histological subtypes of invasive bladder cancer

Abstract This study assessed the diagnostic value of [ 18 F]FDG-PET/CT in staging histological subtypes (HSs) of invasive bladder cancer. In 112 patients with ≥ 75% HS-content, 87% of primary tumours were FDG-avid, 9% were non-assessable (due to high FDG-avid urine), and only 5%...

Molecular imaging tracers targeting c-MET: a systematic review of preclinical evidence and clinical translation

INTRODUCTION: The mesenchymal-epithelial transition factor (c-MET) is an emerging target for molecular imaging owing to its widespread overexpression across multiple cancer types. This systematic review evaluated radioactive and fluorescent c-MET-targeting tracers in preclinical...

Advancing cancer care for adolescents and young adults: the role of the European Network of Expertise

Adolescents and young adults (AYAs, aged 15-39 years at cancer diagnosis) are recognized as a distinct patient group with specific clinical and psychosocial needs requiring tailored care. This article presents the Network of Expertise (NoE) on AYAs with cancer developed through t...

What are the Unmet Needs in Managing Digestive Neuroendocrine Carcinomas?

This review highlights the major unmet needs in diagnosis and treatment of digestive neuroendocrine carcinomas (NEC) and describes the current and evolving evidence on these aspects. Improved pathological criteria are needed to accurately diagnose NEC and distinguish this entity...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should...

Psychometric properties of the Seattle–Groningen Memory Assessment in healthy adults

Brief assessments are increasingly important for scalable and accessible measurement of cognitive function. The Seattle-Groningen Memory Assessment (SGMA) is an accessible memory test that quantifies individual differences in the speed of forgetting through a computational model....

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Correlation of [ 68 Ga]Ga-RAYZ-8009 PET/CT Uptake with Immunohistochemical Glypican-3 Expression in Hepatocellular Carcinoma: A Proof-of-Target Study

Glypican-3, a cell-surface proteoglycan, is overexpressed in most hepatocellular carcinomas (HCCs). Recently, the glypican-3–targeted PET tracer [68Ga]Ga-RAYZ-8009 was shown to enable noninvasive detection of HCC. This retrospective analysis evaluates the correlation between tumo...

Implementation of patient-reported outcome measures in oncology practice: a communication-centered qualitative study on patient and healthcare professional perspectives

Abstract Purpose Patient-reported outcome measures (PROMs) are increasingly used in oncology to support patient-centered care, yet their implementation in routine practice remains inconsistent. Using a communication-centered perspective which conceptualizes PROMs implementation a...

CPPAtools: a computation toolset for chimera protein prediction and analysis

Genetic or non-genetic frameshifting can increase the production of erroneous proteins, with far-reaching impacts on cellular phenotypes, including cancer. While the presence and impact of genetic alterations cannot be foreseen and are often defined clinically following phenotypi...