The Maria Sklodowska-Curie National Research Institute of Oncology

The Prognostic Role of HPV Status Based on the Analysis of Outcomes of Combined Treatment of Oral Cavity and Oropharyngeal Cancers

Background and Objectives: The aim of the paper is to assess the impact of HPV DNA on the survival and cure rates of patients with newly diagnosed head and neck cancers. Materials and Methods: The study group consisted of 51 patients with squamous cell carcinoma of the oral cavit...

Real‐World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON‐3 Study

ABSTRACT Background Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker‐guided treatment strategies, including poly(ADP‐ribose) polymerase inhibitors (PARPi). However, real‐world i...

Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial

Background In classic Hodgkin lymphoma (cHL), identifying high-risk patients is crucial for tailored treatment. Clinical risk factors are useful, but there is room for improvement. Although many diagnostic tissue-based biomarkers have been described to correlate with prognosis, n...

Manganese-Enhanced Magnetic Resonance Imaging: From Translational Research to First-in-Human Trials in Oncology

Manganese-enhanced magnetic resonance imaging (MEMRI) is a functional imaging technique with several potential applications in various research fields. Manganese-enhanced magnetic resonance imaging uses paramagnetic manganese (II) ions (Mn 2+ ) as the contrast enhancer, as they a...

Choosing Between Anti-TROP2 ADCs in Advanced Breast Cancer Without Head-to-Head Evidence: A Practical Evidence-Informed Decision Framework Endorsed by the Polish Society of Clinical Oncology

Background/Objectives: Antibody–drug conjugates (ADCs) targeting trophoblast cell-surface antigen 2 (TROP2), including sacituzumab govitecan (SG) and datopotamab deruxtecan (Dato-DXd), have expanded treatment options for patients with advanced breast cancer. Although both agents...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Tools for providing information to patients about high-tech medical resources for treatment of cancer

BACKGROUND AND PURPOSE: High-tech medical resources play an increasingly important role in cancer diagnosis and treatment. However, accessing information about these technologies remains challenging due to their complexity and a lack of clear information pathways to obtain reliab...

Mapping the evidence base of kidney, prostate and urinary tract tumours to inform the WHO classification of tumours

Background The project ‘World Health Organization (WHO) Classification of Tumours (WCT): a Living Evidence Gap Map by Tumour Type’ applies the Evidence and Gap Map (EGM) methodology to systematically synthesise evidence to support iterative refinements of the WCT. As part of this...

Sex and Mortality Among Patients with Papillary Thyroid Cancer

Importance Unlike patient age, which has been a well-established and routinely used primary biological prognostic factor in the risk stratification of papillary thyroid cancer (PTC), the prognostic value of patient sex remains controversial in this common endocrine malignant neop...

Asparagine Synthetase Deficiency: A Novel ASNS Variant and a Systematic Review of Clinical Phenotypes and Cerebrospinal Fluid Asparagine Levels

Background: Asparagine synthetase deficiency (ASNSD) is a rare autosomal recessive neurometabolic disorder associated with microcephaly, severe developmental impairment, epilepsy, and progressive cerebral atrophy. Reduced cerebrospinal fluid (CSF) asparagine has been proposed as...

DeisoLAB - isotopic envelope identification by analysis of the spatial distribution of peptides in MALDI-MSI data

A new approach (DeisoLAB) is introduced to handle extensive peptide data obtained in mass spectrometry imaging experiments and detect potential isotopic envelopes. It is based on a combination of a fuzzy-inference system and analysis of spatial distribution of peptides. Potential...

Red blood cell‐directed immune responses in COVID ‐19: Mechanisms, clinical evidence and implications for transfusion medicine

Abstract SARS‐CoV‐2 infection is associated with a broad spectrum of red blood cell (RBC)‐directed immune responses, ranging from isolated direct antiglobulin test (DAT) positivity to autoimmune hemolytic anemia (AIHA) and transfusion‐related diagnostic challenges. This narrative...

Tisa-cel and axi-cel CAR structure influences the development of resistance to CD19-CAR-T therapy

CD19-CAR-T cells are a major therapy for relapsed/refractory B-cell malignancies, yet ~50% of patients relapse after infusion. Clinical data suggest that tisa-cel treatment is associated with higher rates of CD19 mutation than axi-cel, though direct comparisons have been lacking....

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner

Methamphetamine (METH) is a known proinflammatory agent; however, the impacts of inflammasomes on its neurotoxic effects are not fully understood. In the present study, we assessed the impact of prolonged METH administration on the hippocampal inflammasome profile in male and fem...

Appropriateness over Numbers: Pharmacological Burden and Scalable Medication Review in Older Adults

Polypharmacy in older adults is common, rising and inconsistently defined, and it is widely treated as a problem of how many medicines a person takes. This non-systematic narrative review argues that its harm depends more on the appropriateness of the regimen and the pharmacologi...

Reflectance confocal microscopy and pathological correlation of tumor microenvironment in adnexal cancers during balstilimab treatment

Adnexal carcinomas (AC) are rare, locally aggressive tumors with limited systemic treatment evidence and no validated immunotherapy biomarkers. Reflectance confocal microscopy (RCM) enables non-invasive, in vivo tumor microenvironment (TME) imaging at near-histologic resolution....

Illness Acceptance Among Adults with Melanoma: A Prospective Observational Cross-Sectional Study

Introduction: Melanoma is a chronic disease that significantly affects patients’ daily functioning and emotional well-being. Beyond its somatic burden, it often leads to substantial changes in quality of life (QoL). This study aimed to assess illness acceptance among melanoma pat...

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

The expression of lysophosphatidic acid and C-reactive protein in the course of the vulvar squamous cell carcinoma and the vulvar lichen sclerosus

OBJECTIVES: In the course of the study the differences regarding both C-reactive protein immune-expression and Lysophosphatidic Acid immune-expression between the stages and histologic grades of the vulvar cancer and the differences between the group of patients diagnosed with li...