The Maria Sklodowska-Curie National Research Institute of Oncology

Inflammasome Inhibitor MCC950 Attenuates Methamphetamine-Induced Hippocampal Neurotoxicity and Aberrant Neurogenesis in a Sex-Dependent Manner

Methamphetamine (METH) is a known proinflammatory agent; however, the impacts of inflammasomes on its neurotoxic effects are not fully understood. In the present study, we assessed the impact of prolonged METH administration on the hippocampal inflammasome profile in male and fem...

Reflectance confocal microscopy and pathological correlation of tumor microenvironment in adnexal cancers during balstilimab treatment

Adnexal carcinomas (AC) are rare, locally aggressive tumors with limited systemic treatment evidence and no validated immunotherapy biomarkers. Reflectance confocal microscopy (RCM) enables non-invasive, in vivo tumor microenvironment (TME) imaging at near-histologic resolution....

Appropriateness over Numbers: Pharmacological Burden and Scalable Medication Review in Older Adults

Polypharmacy in older adults is common, rising and inconsistently defined, and it is widely treated as a problem of how many medicines a person takes. This non-systematic narrative review argues that its harm depends more on the appropriateness of the regimen and the pharmacologi...

Illness Acceptance Among Adults with Melanoma: A Prospective Observational Cross-Sectional Study

Introduction: Melanoma is a chronic disease that significantly affects patients’ daily functioning and emotional well-being. Beyond its somatic burden, it often leads to substantial changes in quality of life (QoL). This study aimed to assess illness acceptance among melanoma pat...

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

The expression of lysophosphatidic acid and C-reactive protein in the course of the vulvar squamous cell carcinoma and the vulvar lichen sclerosus

OBJECTIVES: In the course of the study the differences regarding both C-reactive protein immune-expression and Lysophosphatidic Acid immune-expression between the stages and histologic grades of the vulvar cancer and the differences between the group of patients diagnosed with li...