The Jackson Laboratory for Genomic Medicine

iPSC neurodegenerative disease initiative isogenic CAG repeat iPSC line for Huntington's disease

Purpose of Research: in the KOLF2.1J background as an additional disease series within the iPSC Neurodegenerative Disease Initiative (iNDI) collection. Major Findings: KO, were capable of differentiating to striatal and cortical neurons, astrocytes and microglia using established...

Rates of Evolution Differ Between Cell Types Identified by Single‐Cell RNAseq in Threespine Stickleback

ABSTRACT Rates of evolutionary change vary by gene. While some broad gene categories are highly conserved with little divergence over time, others undergo continuous selection pressure and are highly divergent among populations or species. But such comparative evolutionary studie...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...