The George Institute for Global Health

Glucagon‐Like Peptide‐1 Receptor Agonists in Pregnancy: Periconception Exposure and Perinatal Outcomes

ABSTRACT Objective An increasing number of women of childbearing age worldwide are using glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and are advised to use effective contraception during treatment. Nevertheless, maternity services are encountering increasing numbers of...

Impact of a Mediterranean diet and physical activity intervention on the gut microbiome and faecal metabolites: findings from the MedEx-UK randomised controlled trial

Abstract Diet and physical activity (PA) are potential modulators of the gut microbiome, although research findings are inconsistent, and few studies have explored their combined effects. This study used data from ninety-three participants (forty-seven with pre- and post-interven...

Challenges of clustering disease trajectories in people with multiple long-term conditions using data from 7.2 million patients

Abstract Background Generating clusters of people with similar patterns of Multiple Long-Term Conditions (MLTC) could help target healthcare services for specific patient groups. We aimed to generate data-driven clusters of patients based on their disease trajectories and assess...

Avoiding erroneous decisions: evidence, population impact and acceptability of universal mental health interventions in schools – a commentary on Andrews et al.

Foulkes and colleagues argue many ‘universal’ interventions to prevent mental health problems are harmful (‘inflating prevalence’ because they raise awareness of mental health problems, encouraging those without such problems to misinterpret everyday concerns as symptoms of menta...

Antihypertensive Treatment and Risk of Metabolic Associated Fatty Liver Disease: A Drug-Target Mendelian Randomization

BACKGROUND: Metabolic dysfunction-associated fatty liver disease, conventionally known as nonalcoholic fatty liver disease (NAFLD), affects over a quarter of the global population and lacks approved pharmacological treatments. We investigated whether elevated blood pressure (BP)...

Mobile education builds resilience during shocks in five countries

Abstract Education systems need to withstand frequent shocks, including disease and climate events, which close schools for more than 222 million children 1 . During these emergencies, alternative models are needed to deliver education. However, rigorous evaluation of effective e...

Engagement in women’s health: a history

In parts of the world, patient and public involvement has become an essential part of health and research. In women’s health and research, there is a chronic lack of participation and inclusion of women throughout the research pathway. At the same time, the gender gap and bias in...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Revisiting Obesity Definitions: Impact of the 2025 Lancet Commission Criteria on Obesity Prevalence Among People With MASLD

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Adoption of ‘decentralized’ clinical trial terminology: a systematic review of self-identified decentralized clinical trials

Abstract Importance In recent years, trials have leveraged digital tools and remote methods to improve patient access and diversity, streamline operations, enhance data collection, and reduce costs and timelines. Regulatory terminology has defined these as decentralized clinical...