The Fourth People's Hospital of Ningxia Hui Autonomous Region

Preoperative aggregate index of systemic inflammation and cause-specific 1-year mortality after surgery for geriatric intertrochanteric fracture

Older adults undergoing intertrochanteric-fracture surgery have high 1-year mortality. Routine preoperative complete blood count indices may provide readily available prognostic information before surgery. This prospective single-center cohort enrolled consecutive patients aged ≥...

A Simple Platelet-Centered Coagulation–Inflammation Combined Score for Predicting In-Hospital Mortality in Sepsis

OBJECTIVE: Accurate mortality prediction in sepsis requires assessing coagulation and inflammatory disturbances, yet existing scores are complex or incompletely capture these interconnected processes. We developed and internally validated a simple score combining inflammatory and...

Single-Cell RNA Sequencing deciphers the imbalance of Microenvironment of the Maternal-Fetal Interface in Cesarean Scar Pregnancy.

Cesarean scar pregnancy (CSP) has posed a serious threat to women's reproductive health. The view on its mechanism remained controversial. Here, we performed a single-cell sequencing on villi and decidua from three normal and three cesarean scar pregnancies in patients with a his...

Application and Research Progress of Chinese Herbal Mouthwash in Adjuvant Treatment of Periodontitis

With the continuous advancement of medical research, Chinese herbal medicines have attracted growing attention in the adjuvant treatment of periodontitis, forming an important research field integrating traditional medicine and modern medicine. Periodontitis is a common oral dise...

HIA-MTL: A dynamic hard task mining approach for breast and multi-organ histopathological image classification

Breast cancer is the most common cancer among women worldwide, and its accurate classification based on digital pathology images is crucial for improving treatment precision. However, breast histopathology image classification faces challenges such as coarse-grained annotations a...

Norepinephrine Induces Inflammation- and Injury-Related Changes in Epicardial Adipose-Derived Cells via the p38 MAPK and NF-κB Signaling Pathways and Is Associated With Calcium-Handling Protein Changes and Cellular Injury in H9c2 Cells Exposed to Epicardial Adipose-Derived Cell Culture Media

Background: Norepinephrine may induce inflammatory changes and cellular injury in epicardial adipose-derived cells. This study investigated the effects of norepinephrine on these cells and examined calcium-related responses and cellular injury in H9c2 cells following exposure to...

The ALDW classification for fetal insular morphology: gestational norms and screening utility

To observe the changes in fetal insular morphology with gestational age using the transverse thalamic view, and to preliminarily explore the value of this approach in cases with nervous system abnormalities. Pregnant women between 18 and 34 weeks of gestation who attended the Pek...

EIF1 coordinates transcriptomic and splicing networks associated with cell cycle dysregulation in diabetic retinopathy

Purpose EIF1, an RNA-binding protein implicated in multiple diseases, remains poorly characterized in diabetic retinopathy (DR). This study therefore investigated EIF1 expression and function in an in vitro model of DR pathogenesis. Methods Human retinal pigment epithelial cells...

CSTF2 facilitates ATAD2 translation via m⁶A recognition to drive ER-positive breast cancer metabolic reprogramming and tumor progression

Abstract Objective Breast cancer (BC) is the most common malignancy among women worldwide, accounting for 11.7% of female cancer cases. Cleavage stimulation factor subunit 2 ( CSTF2 ), a key RNA-binding protein, modulates tumor development by influencing N⁶-methyladenosine (m⁶A)...

UBE2S Promotes KIRC Progression by Regulating CDC20 Expression and Suppressing FDX1‐Mediated Cuproptosis, While Promoting M2 Macrophage Polarization

ABSTRACT This study aims to investigate the biological function, molecular mechanisms, and impact on the tumor microenvironment of the ubiquitin‐conjugating enzyme E2S (UBE2S) in the progression of kidney renal clear cell carcinoma (KIRC). Based on the TCGA and GEPIA databases, t...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...