The Fourth People's Hospital

Clinical Evaluation of Bacterial Lysate for Immune Regulation and Exacerbation Reduction in Stable Chronic Obstructive Pulmonary Disease

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide and is accompanied by systemic immune dysfunction, and recurrent acute exacerbations are the main determinants of disease progression, hospitalisation and poor prognos...

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

SLFN5 correlates with tumor immune microenvironment and clinical outcomes of immunotherapy in melanoma

Schlafen family member 5 (SLFN5) has been implicated in melanoma progression, but its expression landscape, immunomodulatory function, and prognostic value for patient survival remain poorly characterized. Here, we systematically analyzed multi-omics datasets, clinical cohorts, h...

Intractable hepatic hydrothorax eliminated by thoraco-peritoneal connection

Rationale: Hepatic hydrothorax occurs in patients with decompensated cirrhosis and has a significantly adverse prognosis. However, several treatments, including indwelling pleural catheters, trans jugular intrahepatic systemic shunts, and automatic low-flow ascites pumps (Alfa pu...

A Bridge From the Gut: Azithromycin Links to AMPK/SIRT1 Activation, Rectifies Th17/Treg Balance and Alleviates COPD Associated With Gut Microbiota-TMAO Modulation

Background: The intestinal microbial ecosystem has emerged as an important contributor to chronic obstructive pulmonary disease (COPD) pathogenesis. Azithromycin (AZI), a commonly used therapeutic agent for COPD, has antibacterial and anti-inflammatory effects. This study aims to...

Intratumoral and peritumoral CT radiomics-clinical feature fusion model for differentiating pulmonary tuberculosis and pulmonary cryptococcosis nodules

Abstract Objective To investigate the clinical value of a fusion model combining intratumoral and peritumoral CT radiomics features with clinical features for differentiating pulmonary tuberculosis (PTB) from pulmonary cryptococcosis (PC) nodules, and to develop a predictive tool...

Niche-dependent immunometabolic regulation of tissue repair and regeneration

Tissue repair restores structural integrity and functional homeostasis after injury through coordinated interactions among immune cells, structural compartments, and extracellular matrix remodeling, ultimately culminating in tissue-resident regenerative programs. Increasing evide...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...

Pathways to medication adherence: a configurational analysis of psychiatric symptoms and medication attitude in patients with schizophrenia spectrum disorder receiving long-acting injectable antipsychotics

Medication non-adherence affects nearly half of patients with schizophrenia spectrum disorder and is associated with relapse and hospitalization. Long-acting injectable (LAI) antipsychotics may improve adherence, but their effectiveness likely depends on interactions between spec...

Bioinformatics-based analysis of key genes associated with endoplasmic reticulum stress in myocardial infarction

Abstract Background Endoplasmic reticulum stress (ERS) is a critical pathological factor that drives myocardial infarction (MI) progression. This study aimed to screen and validate core ERS-related hub genes involved in acute myocardial infarction (AMI) pathogenesis by integratin...