The First People's Hospital of Zhaoqing

IRP2 contributes to COPD-associated hypoxic epithelial injury through regulation of Sestrin2-related stress responses and ferroptosis

Chronic obstructive pulmonary disease (COPD) is characterized by persistent oxidative stress and airway epithelial injury. However, the molecular mechanisms linking iron metabolism and cellular stress responses in COPD remain unclear. This study aimed to investigate the role of i...

Genetic prioritization and multi-omic characterization of GNS-associated thromboinflammatory signatures in venous thromboembolism

Venous thromboembolism (VTE) remains a major cause of cardiovascular morbidity and mortality. Beyond dysregulated coagulation, accumulating evidence implicates immune and inflammatory pathways in thromboinflammatory susceptibility. However, the genetic determinants of VTE and the...

A five-gene TAM and MYCN signature predicts prognosis and identifies MTHFD2 as a therapeutic target in neuroblastoma

Tumor-associated macrophages (TAMs) are key components of the tumor immune-suppressive microenvironment. However, studies focusing on the modulation of TAM-specific gene signatures to improve neuroblastoma (NB) prognosis are limited. MYCN amplification (MNA) is known to influence...