The First People's Hospital of Changde

Ferroptosis-related immune microenvironment and prognostic signature in high-grade endometrial carcinoma: integrated bulk and single-cell analysis

Abstract Background High-grade (FIGO Grade 3) uterine corpus endometrial carcinoma (UCEC) is an aggressive malignancy with limited therapeutic options and a poor prognosis. While ferroptosis is implicated in various cancers, its specific role within the tumor immune microenvironm...

Association between dental caries experience measured by dmft and oral health-related quality of life among preschool children: a cross-sectional study

Abstract Objective To examine the association between dental caries experience, measured using the decayed, missing, and filled deciduous teeth index (dmft), and parent-reported oral health-related quality of life (OHRQoL) among preschool children in Changde, northwestern Hunan,...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Potential of plasma metagenomic next-generation sequencing to guide antibiotic therapy in acute necrotizing pancreatitis with early fever: a prospective multicenter cohort study

Indiscriminate antibiotic use remains common in febrile patients with acute necrotizing pancreatitis (ANP), particularly during the early phase. Metagenomic next‑generation sequencing (mNGS) has shown diagnostic utility for infected pancreatic necrosis (IPN) and may offer a means...

SIRT3-dependent mitochondrial redox homeostasis protects against age-related tendon degeneration

Aims: Mitochondrial redox homeostasis is closely linked to the ageing processes of tendons, whether in normal or pathological conditions. This study employed an innovative approach to examine the role of sirtuin 3 (SIRT3) in mitochondrial dysfunction in the aged murine supraspina...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

ABSTRACT Metabolic remodeling is one of the hallmarks of malignant tumors, and post‐translational modifications of proteins, such as succinylation, play an important role in the process of metabolic remodeling by regulating the function of metabolic enzymes. However, the role of...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...

Comprehensive multi-omics landscape exploration and functional characterization of TACSTD2 throughout pan-cancer

Tumor-associated calcium signal transducer 2 ( TACSTD2 ) is widely investigated in cancer research. Its overexpression across multiple cancers is linked to elevated tumor aggressiveness, metastasis, and poor prognosis, making it a potential biomarker for diagnosis, prognosis, and...

Trade-Offs Among Arc Erosion Resistance, Wear Resistance, and Compressive Performance: Designing Cu-Nb-Gr Composites with a Semi-Continuous Gr-Rich Structure Coupled with an Nb-Rich Load-Bearing Structure

Developing Cu-based composites with excellent electrical and mechanical properties under multiphysics-coupled service conditions remains challenging. Novel Cu-Nb-Gr composites were fabricated by high-energy ball milling and High-pressure Multi-field Assisted Rapid Sintering. Expe...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model

Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying axis between oxidative stress and the nec...