The First Hospital of Changsha

How medical students experience disease-related information processing when a family member has cancer: a qualitative study

Communication of disease-related information in cancer care involves not only patients but also family members. In the Chinese family context, family members are often involved in obtaining, communicating, and processing illness-related information. However, little is known about...

Complications and revisions of inlay versus onlay design for reverse shoulder arthroplasty: a meta analysis and systematic review

Reverse total shoulder arthroplasty (RTSA) is the standard treatment for rotator cuff tear arthropathy; humeral stems are classified as inlay or onlay, but their comparative risks of complications and revision remain unclear. This systematic review evaluates these outcomes to inf...

Fibroblast growth factor 21 is linked to ambient temperature-dependent regulation of pathological cardiac hypertrophy in UCP1 knockout mice

Adipocytes play an important role in the regulation of cardiovascular health and disease. However, the molecular mechanisms underlying the endocrine role of brown adipose tissue (BAT) in pathological cardiac remodeling remain unclear. Herein, we show that uncoupling protein 1 (UC...

Tyrosine protein kinase ABL1 regulates the mTOR/ULK1 pathway to alleviate postoperative cognitive dysfunction in aged mice.

BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common and serious complication in older adult patients. While the tyrosine kinase ABL1 has been implicated in neurodegenerative diseases, its specific role in POCD remains unexplored. This study aims to investigate whet...

Nomogram model based on dual-energy CT quantitative parameters and radiomics for preoperative prediction of microvascular invasion in hepatocellular carcinoma

Abstract Objective To explore the potential value of a nomogram model based on dual-energy CT (DECT) quantitative parameters and radiomics for preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma. Methods A retrospective analysis was conducted on 14...