The Fifth People’s Hospital of Suzhou

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

AIMS: Crisugabalin (HSK16149), a selective γ-aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. MATERIALS AND...

Solvation‐Regulated Fluorinated Gel Polymer Electrolyte for Fast Li + Transport and Interphase Stabilization in Lithium Metal Batteries

ABSTRACT The development of gel polymer electrolytes (GPEs) with high ionic conductivity and stable electrode/electrolyte interface is crucial for realizing high‐energy‐density lithium metal batteries. In this work, a composite GPE is designed by incorporating 2,2,2‐trifluoroethy...

Highly Sensitive Electrochemical Biosensing Strategy Based on Multiple CRISPR/Cas12a Trans -Cleavage Units

Abstract This study presents the assembly of multiple CRISPR/Cas12a units by target-induced hybridization chain reaction (HCR), which is capable of highly sensitive electrochemical detection of target miRNA. The confinement effect of the HCR/Cas12a system is demonstrated, which s...

Hierarchical multitask learning for upper extremity rehabilitation assessment using wearable sensors

Upper extremity motor impairment following stroke critically limits patients’ functional independence, making continuous and objective rehabilitation assessment vital for guiding recovery. Current clinical evaluations remain largely subjective, confined to clinical settings, and...

Gut microbiota dysbiosis correlates with reduced drug exposure in patients with multidrug-resistant tuberculosis

Although systemic exposure to anti-tuberculosis agents is critical for therapeutic efficacy, substantial inter-individual variability of drug exposure persists despite standardized dosing. Emerging studies suggest that the gut microbiota may influence drug metabolism and host pha...

Multidimensional Sensing in Flexible Violet Phosphorus Photodetectors Driven by the Bulk Photovoltaic Effect

ABSTRACT The bulk photovoltaic effect (BPVE) generates zero bias photocurrents in systems with broken inversion symmetry, offering a junction free pathway for self‐powered optoelectronic devices and conceptually overcoming the Shockley‐Queisser efficiency limit of conventional ju...